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Br J Nutr. 2004 Jun;91(6):943-50. Related Articles, Links
Oxidative stress status in an institutionalised elderly
group after the intake of a phenolic-rich dessert.
Carmen Ramirez-Tortosa M, Garcia-Alonso J, Luisa Vidal-
Guevara M, Quiles JL, Jesus Periago M, Linde J, Dolores Mesa
M, Ros G, Abellan P, Gil A.
Department of Biochemistry and Molecular Biology, Institute
of Nutrition and Food Technology, University of Granada,
Campus de Cartuja, 18071 Granada, Spain.
The elderly population undergoes a series of physiological
and sociological changes common to old age with a high
probability of suffering degenerative illness and
malnutrition. A dessert rich in phenolic compounds has been
designed by using concentrated juices of grape, cherry,
blackberry, blackcurrant and raspberry with the aim of it
being used as a complementary food in adulthood. In the
present study, we investigated the effect of the intake of
this dessert (a jar of 200 g daily for a period of 2 weeks),
with an antioxidant activity equivalent to ten servings of
fruits and vegetables, on several markers of oxidative and
antioxidant status in DNA and plasma in a group of elderly
individuals. Non-smoking institutionalised elderly subjects
were recruited from a pool of volunteers in an old-age home
in Murcia (Spain). Twenty-two subjects (six men and sixteen
women) participated in the study. The study was designed as
a randomised intervention trial with a period of 2 weeks. At
days 1 and 15, blood samples were collected to analyse total
antioxidant capacity, biochemical parameters, antioxidant
vitamins, LDL peroxidation, and DNA damage in peripheral
blood lymphocytes. The conclusion of the present study is
that a 2-week intervention with our dessert enriched with
natural polyphenol compounds in elderly individuals does not
give enough time to find changes in the antioxidant and
oxidative status. Also, the view that the marked antioxidant
ability of polyphenols in vitro does not translate to
analogous effects in vivo was confirmed. Moreover, a highly
oxidative stress status during ageing was confirmed,
together with the need to perform follow-up nutritional
studies to improve this situation.
PMID: 15182397 [PubMed - in process]
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Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/)
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Oxidative stress status in an institutionalised elderly
group after the intake of a phenolic-rich dessert.
Carmen Ramirez-Tortosa M, Garcia-Alonso J, Luisa Vidal-
Guevara M, Quiles JL, Jesus Periago M, Linde J, Dolores Mesa
M, Ros G, Abellan P, Gil A.
Department of Biochemistry and Molecular Biology, Institute
of Nutrition and Food Technology, University of Granada,
Campus de Cartuja, 18071 Granada, Spain.
The elderly population undergoes a series of physiological
and sociological changes common to old age with a high
probability of suffering degenerative illness and
malnutrition. A dessert rich in phenolic compounds has been
designed by using concentrated juices of grape, cherry,
blackberry, blackcurrant and raspberry with the aim of it
being used as a complementary food in adulthood. In the
present study, we investigated the effect of the intake of
this dessert (a jar of 200 g daily for a period of 2 weeks),
with an antioxidant activity equivalent to ten servings of
fruits and vegetables, on several markers of oxidative and
antioxidant status in DNA and plasma in a group of elderly
individuals. Non-smoking institutionalised elderly subjects
were recruited from a pool of volunteers in an old-age home
in Murcia (Spain). Twenty-two subjects (six men and sixteen
women) participated in the study. The study was designed as
a randomised intervention trial with a period of 2 weeks. At
days 1 and 15, blood samples were collected to analyse total
antioxidant capacity, biochemical parameters, antioxidant
vitamins, LDL peroxidation, and DNA damage in peripheral
blood lymphocytes. The conclusion of the present study is
that a 2-week intervention with our dessert enriched with
natural polyphenol compounds in elderly individuals does not
give enough time to find changes in the antioxidant and
oxidative status. Also, the view that the marked antioxidant
ability of polyphenols in vitro does not translate to
analogous effects in vivo was confirmed. Moreover, a highly
oxidative stress status during ageing was confirmed,
together with the need to perform follow-up nutritional
studies to improve this situation.
PMID: 15182397 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/)
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
