Doe
http://news.bbc.co.uk/1/hi/health/3795349.stm
Parasite reaction link to asthma
Asthmatics were found to have high chitinase levels A faulty
immune reaction - where the body reacts to non-existent
parasites - could trigger asthma, a study suggests. Yale
University scientists found high levels of an enzyme called
chitinase, produced by the immune system, soar in mice with
asthma-like disease.
The enzyme is linked to parasites because it breaks down
chitin, found on the surfaces of parasites and insects.
Writing in Science, the researchers say their findings may
lead to new ways of treating asthma.
Exciting results such as these provide clues that will
help us to begin to unravel the complex processes involved
in the inflammation of the airways
Matthew Hallsworth, Asthma UK In their study, the Yale team
found that those mice not bred to have the asthma-like
disease had far less chitinase.
Lung tissue from humans with asthma also showed high levels
of chitinase. The enzyme was undetectable in tissue from
people who did not have the disease.
Overproduction of the enzyme was found to depend on a
protein in the immune system called interleukin-13.
Extra IL-13, common in the lungs of asthmatics, is thought
to help spark asthma attacks.
Phantom parasites
In simple creatures, such as worms and flies, chitinase is
thought to protect against parasitic invasion.
Humans possess around half a dozen chitinase genes, but it
was believed these were simply evolutionary relics.
However, the Yale University research suggests they might be
stirred into action in asthmatics.
Their findings support a theory about the origins of asthma,
which suggested t it is sparked off by the body sensing
parasites when none are there.
That, it is thought, sends the immune system into overdrive,
producing inflammation in the airways and asthma attacks.
The Yale researchers, led by Dr Jack Elias say human
chitinase could be a useful new target for anti-asthma
drugs.
Matthew Hallsworth, research development manager at Asthma
UK, said: "It has long been suspected that there are many
similarities between the body's response to parasites and
the development of allergic conditions such as asthma.
"Exciting results such as these provide clues that will help
us to begin to unravel the complex processes involved in the
inflammation of the airways."
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Thought this might go right along with .. that ..
<<snip>> the highest levels of plasma chitotriosidase were
observed in patients with the highest degree of iron
overload, suggesting that this factor could trigger
chitotriosidase overproduction. <<snip>>
PMID: 11282098 [PubMed - indexed for MEDLINE]
http://tinyurl.com/248cd
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http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Parasite reaction link to asthma
Asthmatics were found to have high chitinase levels A faulty
immune reaction - where the body reacts to non-existent
parasites - could trigger asthma, a study suggests. Yale
University scientists found high levels of an enzyme called
chitinase, produced by the immune system, soar in mice with
asthma-like disease.
The enzyme is linked to parasites because it breaks down
chitin, found on the surfaces of parasites and insects.
Writing in Science, the researchers say their findings may
lead to new ways of treating asthma.
Exciting results such as these provide clues that will
help us to begin to unravel the complex processes involved
in the inflammation of the airways
Matthew Hallsworth, Asthma UK In their study, the Yale team
found that those mice not bred to have the asthma-like
disease had far less chitinase.
Lung tissue from humans with asthma also showed high levels
of chitinase. The enzyme was undetectable in tissue from
people who did not have the disease.
Overproduction of the enzyme was found to depend on a
protein in the immune system called interleukin-13.
Extra IL-13, common in the lungs of asthmatics, is thought
to help spark asthma attacks.
Phantom parasites
In simple creatures, such as worms and flies, chitinase is
thought to protect against parasitic invasion.
Humans possess around half a dozen chitinase genes, but it
was believed these were simply evolutionary relics.
However, the Yale University research suggests they might be
stirred into action in asthmatics.
Their findings support a theory about the origins of asthma,
which suggested t it is sparked off by the body sensing
parasites when none are there.
That, it is thought, sends the immune system into overdrive,
producing inflammation in the airways and asthma attacks.
The Yale researchers, led by Dr Jack Elias say human
chitinase could be a useful new target for anti-asthma
drugs.
Matthew Hallsworth, research development manager at Asthma
UK, said: "It has long been suspected that there are many
similarities between the body's response to parasites and
the development of allergic conditions such as asthma.
"Exciting results such as these provide clues that will help
us to begin to unravel the complex processes involved in the
inflammation of the airways."
------------------------------------------------------------
--------------
-------------------------------
Thought this might go right along with .. that ..
<<snip>> the highest levels of plasma chitotriosidase were
observed in patients with the highest degree of iron
overload, suggesting that this factor could trigger
chitotriosidase overproduction. <<snip>>
PMID: 11282098 [PubMed - indexed for MEDLINE]
http://tinyurl.com/248cd
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
