Iron / stroke

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Ageing Res Rev. 2004 Jul;3(3):345-53. Related Articles, Links

The role of iron neurotoxicity in ischemic stroke.

Selim MH, Ratan RR.

Department of Neurology, Division of Cerebrovascular
Diseases, Harvard Medical School, Beth Israel Deaconess
Medical Center, 330 Brookline Avenue, Palmer 127, Boston, MA
02215, USA.

Stroke is the second leading cause of death worldwide, and
its incidence is expected to rise with the projected
increase in the number of aging population. Disturbances of
brain iron homeostasis have been linked to acute neuronal
injury following cerebral ischemia. Free iron catalyzes the
conversion of superoxide and hydrogen peroxide into hydroxyl
radicals, which promote oxidative stress leading to
subsequent cell death/apoptosis. In recent years,
considerable evidence has emerged regarding the role of iron
neurotoxicity following experimental cerebral ischemia. Few
clinical studies have also attempted to investigate the role
of iron in stroke patients. The present review will examine
the currently available evidence for iron-mediated
neurotoxicity and the potential mechanisms underlying
deregulation of iron homeostasis in the brain following
cerebral ischemia. Understanding the changes in brain iron
metabolism and its relationship to neuronal injury in
ischemic stroke could provide new therapeutic targets to
improve the outcome of stroke patients.

PMID: 15231241 [PubMed - in process]

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