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Free Radic Biol Med. 2004 Aug 1;37(3):411-21. Related Articles, Links
Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane
concentrations in humans.
Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe
T, Sies H.
Institut fur Klinische Chemie und Pathobiochemie, Otto-von-Guericke-
Universitat Magdeburg, Germany.
Flavan-3-ols are potent antioxidants in vitro, but
convincing evidence for antioxidant action in vivo is
lacking. We examined whether an oxidative stress-mediated
increase in plasma F(2)-isoprostanes is counteracted by a
flavanol-rich cocoa beverage. Twenty volunteers were
examined in a comparative randomized double-blind crossover
design with respect to ingestion of high-flavanol cocoa
drink (HFCD; 187 mg flavan-3-ols/100 ml) vs. low-flavanol
cocoa drink (LFCD; 14 mg/100 ml). With 10 individuals, the
treatment was combined with strenuous physical exercise.
Total (esterified plus nonesterified) F(2)-isoprostanes were
analyzed by GC/MS. LFCD caused a slight increase in the mean
(+/- SEM) plasma concentrations of F(2)-isoprostanes 2 and 4
h after intake (2.16 +/- 0.19 nM at 4 h vs. 1.76 +/- 0.11 nM
at 0 h, n = 10), which may be attributable to postprandial
oxidative stress. This increase did not occur with HFCD
(1.57 +/- 0.06 nM at 4 h vs. 1.65 +/- 0.10 nM at 0 h, n =
10). The difference in F(2)-isoprostanes 2 and 4 h after
intake of HFCD vs. LFCD became statistically significant
when the intake was combined with physical exercise (P <
0.01, ANOVA). We conclude that dietary flavanols, using
cocoa drink as example, can lower the plasma level of F(2)-
isoprostanes, indicators of in vivo lipid peroxidation.
PMID: 15223075 [PubMed - in process]
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Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane
concentrations in humans.
Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe
T, Sies H.
Institut fur Klinische Chemie und Pathobiochemie, Otto-von-Guericke-
Universitat Magdeburg, Germany.
Flavan-3-ols are potent antioxidants in vitro, but
convincing evidence for antioxidant action in vivo is
lacking. We examined whether an oxidative stress-mediated
increase in plasma F(2)-isoprostanes is counteracted by a
flavanol-rich cocoa beverage. Twenty volunteers were
examined in a comparative randomized double-blind crossover
design with respect to ingestion of high-flavanol cocoa
drink (HFCD; 187 mg flavan-3-ols/100 ml) vs. low-flavanol
cocoa drink (LFCD; 14 mg/100 ml). With 10 individuals, the
treatment was combined with strenuous physical exercise.
Total (esterified plus nonesterified) F(2)-isoprostanes were
analyzed by GC/MS. LFCD caused a slight increase in the mean
(+/- SEM) plasma concentrations of F(2)-isoprostanes 2 and 4
h after intake (2.16 +/- 0.19 nM at 4 h vs. 1.76 +/- 0.11 nM
at 0 h, n = 10), which may be attributable to postprandial
oxidative stress. This increase did not occur with HFCD
(1.57 +/- 0.06 nM at 4 h vs. 1.65 +/- 0.10 nM at 0 h, n =
10). The difference in F(2)-isoprostanes 2 and 4 h after
intake of HFCD vs. LFCD became statistically significant
when the intake was combined with physical exercise (P <
0.01, ANOVA). We conclude that dietary flavanols, using
cocoa drink as example, can lower the plasma level of F(2)-
isoprostanes, indicators of in vivo lipid peroxidation.
PMID: 15223075 [PubMed - in process]
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
