Doe
Fam Med. 2004 May
The combined effect of transferrin saturation and low
density lipoprotein on mortality.
Wells BJ, Mainous AG 3rd, King DE, Gill JM, Carek PJ,
Geesey ME.
Department of Family Medicine, Medical University of South
Carolina, Charleston 29425, USA. wellsbj@musc.edu
BACKGROUND AND OBJECTIVES: Evidence suggests that
cardiovascular disease (CVD) is accelerated by the oxidation
of low-density lipoprotein (LDL) in the presence of iron.
This study examined whether adults with elevated iron, as
measured by transferrin saturation (TS), and elevated LDL
are at an increased risk for mortality. METHODS: This is a
cohort study of the adult US population using the National
Health and Nutrition Examination Survey 1976-1980 (NHANES
II) merged with the NHANES II Mortality Study in 1992.
Multivariate Cox regression was performed to determine
hazard ratios (HR) for CVD and all-cause mortality for
high (>55%) or low (<55%) levels of TS and high (>160
mg/dl) or low (<160 mg/dl) levels of LDL. RESULTS: An
elevated LDL alone did not significantly increase CVD
mortality or all-cause mortality in the adjusted model.
Individuals with elevated LDL and elevated TS had a
statistically significant increase in both CVD mortality
and all-cause mortality (HR=5.74 and
3.53, respectively) compared to the low LDL and low TS
group. CONCLUSIONS: The results of this study indicate an
increased risk associated with the combination of elevated
LDL and elevated TS, which suggests that iron-mediated
oxidation of LDL may be a significant factor in the
progression of CVD.
http://tinyurl.com/3guhl
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Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
The combined effect of transferrin saturation and low
density lipoprotein on mortality.
Wells BJ, Mainous AG 3rd, King DE, Gill JM, Carek PJ,
Geesey ME.
Department of Family Medicine, Medical University of South
Carolina, Charleston 29425, USA. wellsbj@musc.edu
BACKGROUND AND OBJECTIVES: Evidence suggests that
cardiovascular disease (CVD) is accelerated by the oxidation
of low-density lipoprotein (LDL) in the presence of iron.
This study examined whether adults with elevated iron, as
measured by transferrin saturation (TS), and elevated LDL
are at an increased risk for mortality. METHODS: This is a
cohort study of the adult US population using the National
Health and Nutrition Examination Survey 1976-1980 (NHANES
II) merged with the NHANES II Mortality Study in 1992.
Multivariate Cox regression was performed to determine
hazard ratios (HR) for CVD and all-cause mortality for
high (>55%) or low (<55%) levels of TS and high (>160
mg/dl) or low (<160 mg/dl) levels of LDL. RESULTS: An
elevated LDL alone did not significantly increase CVD
mortality or all-cause mortality in the adjusted model.
Individuals with elevated LDL and elevated TS had a
statistically significant increase in both CVD mortality
and all-cause mortality (HR=5.74 and
3.53, respectively) compared to the low LDL and low TS
group. CONCLUSIONS: The results of this study indicate an
increased risk associated with the combination of elevated
LDL and elevated TS, which suggests that iron-mediated
oxidation of LDL may be a significant factor in the
progression of CVD.
http://tinyurl.com/3guhl
------------------------------------------------------------
--------------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
