Doe
Elevated iron indices in patients with diabetes. Diabet
Med. 2004 Jul
Thomas MC, MacIsaac RJ, Tsalamandris C, Jerums G.
Department of Medicine, University of Melbourne, Austin and
Repatriation Medical Center, Heidelberg, Victoria,
Australia.
Abstract Aims Excess iron has been implicated in the
pathogenesis of diabetes and its complications. This study
documents the assessment of plasma iron indices and the
correlation between transferrin saturation with biochemical
and clinical parameters in a cross-sectional survey of 820
patients with diabetes in long-term follow-up in a single
clinic. Methods Plasma iron indices, together with the
biochemical and clinical profile of all patients, were
recorded over a 2-year period. Predictors of the transferrin
saturation were identified using multiple and logistic
regression analysis. Results Eighty per cent of patients had
Type 2 diabetes. The prevalence of elevated transferrin
saturation (> 35%) was 3-4-fold higher in patients with
diabetes, compared with historical prevalence described in
the general population. Independent associations with
elevated transferrin saturation were male gender, low C-
reactive protein, and increased fasting plasma glucose (all
P < 0.0001). Patients with Type 1 diabetes were also more
likely to have an elevated transferrin saturation [odds
ratio 3.9 (95% CI 1.9-8.0), P < 0.001]. Patients with an
elevated transferrin saturation were younger, but had a
similar duration of diabetes, possibly suggesting an earlier
age of onset. There was no correlation between the presence
of diabetic complications and the presence of elevated iron
indices. Conclusions Elevated iron indices are more common
in patients with diabetes. Excess iron may have a role in
the development of diabetes and subsequently in glycaemic
control. This should be balanced by the strong association
between iron indices and anaemia in patients with diabetes.
Diabet. Med. 21, 798-802 (2004)
PMID: 15209778 [PubMed - in process]
------------------------------------------------------------
---------------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Med. 2004 Jul
Thomas MC, MacIsaac RJ, Tsalamandris C, Jerums G.
Department of Medicine, University of Melbourne, Austin and
Repatriation Medical Center, Heidelberg, Victoria,
Australia.
Abstract Aims Excess iron has been implicated in the
pathogenesis of diabetes and its complications. This study
documents the assessment of plasma iron indices and the
correlation between transferrin saturation with biochemical
and clinical parameters in a cross-sectional survey of 820
patients with diabetes in long-term follow-up in a single
clinic. Methods Plasma iron indices, together with the
biochemical and clinical profile of all patients, were
recorded over a 2-year period. Predictors of the transferrin
saturation were identified using multiple and logistic
regression analysis. Results Eighty per cent of patients had
Type 2 diabetes. The prevalence of elevated transferrin
saturation (> 35%) was 3-4-fold higher in patients with
diabetes, compared with historical prevalence described in
the general population. Independent associations with
elevated transferrin saturation were male gender, low C-
reactive protein, and increased fasting plasma glucose (all
P < 0.0001). Patients with Type 1 diabetes were also more
likely to have an elevated transferrin saturation [odds
ratio 3.9 (95% CI 1.9-8.0), P < 0.001]. Patients with an
elevated transferrin saturation were younger, but had a
similar duration of diabetes, possibly suggesting an earlier
age of onset. There was no correlation between the presence
of diabetic complications and the presence of elevated iron
indices. Conclusions Elevated iron indices are more common
in patients with diabetes. Excess iron may have a role in
the development of diabetes and subsequently in glycaemic
control. This should be balanced by the strong association
between iron indices and anaemia in patients with diabetes.
Diabet. Med. 21, 798-802 (2004)
PMID: 15209778 [PubMed - in process]
------------------------------------------------------------
---------------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
