Doe
Exp Biol Med (Maywood). 2004 Jul;229(7):607-15. Related Articles, Links
Oxidative stress plays an important role in the pathogenesis
of drug-induced retinopathy.
Toler SM.
Clinical Safety and Risk Management, Pfizer Inc., Pfizer
Global Research and Development, 50 Pequot Avenue, New
London, CT 06320. steven_m_toler@groton.pfizer.com
Several pharmaceutical agents have been associated with rare
but serious retinopathies, some resulting in blindness.
Little is known of the mechanism(s) that produce these
injuries. Mechanisms proposed thus far have not been
embraced by the medical and scientific communities. However,
preclinical and clinical data indicate that oxidative stress
may contribute substantially to iatrogenic retinal disease.
Retinal oxidative stress may be precipitated by the
interaction of putative retinal toxins with the ocular redox
system. The retina, replete with cytochromes P450 and
myeloperoxidase, may serve to activate xenobiotics to
oxidants, resulting in ocular injury. These activated agents
may directly form retinal adducts or may diminish ocular
reduced glutathione concentrations. Data are reviewed that
suggest that indomethacin, tamoxifen, thioridazine, and
chloroquine all produce retinopathies via a common mechanism-
they produce ocular oxidative stress.
PMID: 15229354 [PubMed - in process]
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http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
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Oxidative stress plays an important role in the pathogenesis
of drug-induced retinopathy.
Toler SM.
Clinical Safety and Risk Management, Pfizer Inc., Pfizer
Global Research and Development, 50 Pequot Avenue, New
London, CT 06320. steven_m_toler@groton.pfizer.com
Several pharmaceutical agents have been associated with rare
but serious retinopathies, some resulting in blindness.
Little is known of the mechanism(s) that produce these
injuries. Mechanisms proposed thus far have not been
embraced by the medical and scientific communities. However,
preclinical and clinical data indicate that oxidative stress
may contribute substantially to iatrogenic retinal disease.
Retinal oxidative stress may be precipitated by the
interaction of putative retinal toxins with the ocular redox
system. The retina, replete with cytochromes P450 and
myeloperoxidase, may serve to activate xenobiotics to
oxidants, resulting in ocular injury. These activated agents
may directly form retinal adducts or may diminish ocular
reduced glutathione concentrations. Data are reviewed that
suggest that indomethacin, tamoxifen, thioridazine, and
chloroquine all produce retinopathies via a common mechanism-
they produce ocular oxidative stress.
PMID: 15229354 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
