Doe
Arch Soc Esp Oftalmol. 2004 Jun;79(6):289-94. Related Articles, Links
[Oxidative stress in a model for experimental diabetic
retinopathy: treatment with antioxidants]
[Article in Spanish]
Miranda M, Muriach M, Johnsen S, Bosch-Morell F, Araiz J,
Roma J, Romero FJ.
Universidad Cardenal Herrera-CEU y Fundacion Oftalmologica
del Mediterraneo.
PURPOSE: Diabetic retinopathy is the primary cause of
blindness in developed countries, and though strict glycemic
control is desirable to prevent complications, this is not
always achievable. Thus, adjunctive therapies are needed to
help in preventing or delaying the onset of diabetic
complications. We have studied the biochemical and
functional changes in the retina of diabetic mice, and the
ability of ebselen and lutein, two antioxidants, to reverse
these effects, using as a comparison the effect of insulin
therapy. METHODS: Alloxan injection was used to achieve
hyperglycemia. Malondialdehyde
(MDA) concentration in blood and glutathione peroxidase
(GPx) activity in eye homogenate were measured. Serial
electroretinograms (ERG) were recorded. RESULTS: MDA
concentration in the blood was high in diabetic
animals. GPx activity in eye homogenate decreased in
the diabetic conditions. Maximal electroretinogram
amplitude decreased in diabetic animals with respect
to controls. Ebselen and lutein restored MDA levels,
GPx activity and ERG amplitude, and had no effect on
glycemia. CONCLUSION: These results call for further
studies on ebselen or lutein as adequate adjunctive
therapies for diabetes (Arch Soc Esp Oftalmol 2004;
79: 289-294).
PMID: 15221675 [PubMed - in process]
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Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
[Oxidative stress in a model for experimental diabetic
retinopathy: treatment with antioxidants]
[Article in Spanish]
Miranda M, Muriach M, Johnsen S, Bosch-Morell F, Araiz J,
Roma J, Romero FJ.
Universidad Cardenal Herrera-CEU y Fundacion Oftalmologica
del Mediterraneo.
PURPOSE: Diabetic retinopathy is the primary cause of
blindness in developed countries, and though strict glycemic
control is desirable to prevent complications, this is not
always achievable. Thus, adjunctive therapies are needed to
help in preventing or delaying the onset of diabetic
complications. We have studied the biochemical and
functional changes in the retina of diabetic mice, and the
ability of ebselen and lutein, two antioxidants, to reverse
these effects, using as a comparison the effect of insulin
therapy. METHODS: Alloxan injection was used to achieve
hyperglycemia. Malondialdehyde
(MDA) concentration in blood and glutathione peroxidase
(GPx) activity in eye homogenate were measured. Serial
electroretinograms (ERG) were recorded. RESULTS: MDA
concentration in the blood was high in diabetic
animals. GPx activity in eye homogenate decreased in
the diabetic conditions. Maximal electroretinogram
amplitude decreased in diabetic animals with respect
to controls. Ebselen and lutein restored MDA levels,
GPx activity and ERG amplitude, and had no effect on
glycemia. CONCLUSION: These results call for further
studies on ebselen or lutein as adequate adjunctive
therapies for diabetes (Arch Soc Esp Oftalmol 2004;
79: 289-294).
PMID: 15221675 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
