What causes PVC's?

Doe

>Subject: What causes PVC's?
>From: "James E." wer25@example.com
>Date: 7/4/2004 12:17 PM Mountain Daylight Time
>Message-id: <nRXFc.22548$SO5.11097@twister.socal.rr.com>
>
>I am 75 yo male. I had moderate PVC's (Premature
>Ventricular Contractions) about three years ago. A nuclear
>radiology test and a treadmill test were uneventful. No
>action was taken.
>
>The PVC's disappeared within a few months but have recently
>re-appeared. Could they be caused by increased coffee
>consumption, stress or alcohol consumption? Is there a
>common cause for PVC's?
>
>Is there anything I can or should do to make them go away?
>They don't really interfere with my lifestyle. Just an
>occasional "rumble" in my chest. Have mild diabetes but am
>otherwise in good health.
>
>--
>James

This article speaks to the results of inductioon of iron
overload in the gerbil ..

Dr. Jerome Sullivan has been attempting to explain the
implications of too much iron in our diets and its'
effects on the heart ..

J Lab Clin Med. 2003 Feb;141(2):121-30. Related
Articles, Links

Comment in: J Lab Clin Med. 2004 Feb;143(2):130-2; author
reply 133-4.

Deferoxamine promotes survival and prevents
electrocardiographic abnormalities in the gerbil model of
iron-overload cardiomyopathy.

Obejero-Paz CA, Yang T, Dong WQ, Levy MN, Brittenham GM,
Kuryshev YA, Brown AM.

Rammelkamp Center for Education and Research, MetroHealth
Campus, Cleveland, OH 44109, USA.

We investigated the time course of electrocardiographic
(ECG) changes in the Mongolian gerbil model of iron overload
and the effects of the iron chelator deferoxamine (DFO) on
these changes. Iron overload was produced with weekly
subcutaneous injections of low doses (200 mg/kg/wk) or high
doses (800
Ds/kg/wk) of iron-dextran. DFO was administered
subcutaneously at a dose of 200
Dt/kg/day to high-dose animals. Our results show that (1)
survival of iron-overloaded gerbils is dose-dependent,
with median survival times of 68 and 14 weeks for low-
and high-dose animals, respectively; (2) both low and
high doses produce prolongation of the PR interval and
bradycardia in early stages and prolongation of the QT
interval, premature ventricular contractions, variable
degrees of atrioventricular block, changes in the ST
segment, and T-wave inversion at later stages coinciding
with the development of heart failure; (3) DFO prevented
death during 20 weeks of high-dose iron-dextran; (4) DFO
prevented ECG changes, although delayed prolongation of
PR intervals and QRS complexes occurred; and (5) despite
marked prolongation of survival and prevention of ECG
changes, DFO had modest effects on total cardiac iron
content. We speculate that DFO chelates a small iron pool
located within the cytoplasm of iron-overloaded
cardiomyocytes.

PMID: 12577048 [PubMed - indexed for MEDLINE]

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