Doe
Dig Dis Sci. 2004 Apr;49(4):565-71. Related Articles, Links
Selective granulocyte and monocyte adsorptive apheresis as a
first-line treatment for steroid naive patients with active
ulcerative colitis: a prospective uncontrolled study.
Suzuki Y, Yoshimura N, Saniabadi AR, Saito Y.
Department of Internal Medicene, Sakura Hospital, Faculty of
Medicine, Toho University, 564-1 Shimoshizu, Sakura City,
Chiba 285-874, Japan. yasuo-suzuki@sakura.med.toho-u.ac.jp
Corticosteroid therapy of ulcerative colitis (UC) is
associated with frequent adverse side effects and poor
quality of life. Recently, adsorptive granulocyte and
monocyte/macrophage apheresis has shown efficacy in patients
with severe steroid refractory UC. The objective of this
study was to investigate if, instead of corticosteroids,
adsorptive leukocytapheresis has efficacy as the first-line
therapy for steroid-naive patients with active UC. Twenty
patients, aged 15-49 years, with a mean clinical activity
index (CAI) of 8.6 were recruited. Adsorptive
leukocytapheresis was done with Adacolumn, which contains
cellulose acetate beads as adsorptive carriers for
granulocytes and monocytes (FcgammaR and complement
receptors expressing leukocytes). Each patient received 6 to
10 leukocytapheresis sessions of 60-min duration, at 2
sessions/week. Efficacy was assessed 1 week after the last
session. Post treatment, the mean CAI was 3.0 (P = 0001),
and 17 of 20 patients (85%) were in remission. There were
significant falls in C-reactive protein (P = 0.0003), total
white cell counts (P = 0.003), neutrophils (P = 0.0029), and
monocytes (P
= .0038), an increase in lymphocytes (P = 0.001), and
= increases in the blood
levels of soluble TNF-alpha receptors I (P = 0.0007) and II
(P = 0.0045) in the column outflow (blood return to the
patients). Further, at 8 months, 60% of patients had
maintained their remission. No severe side effects were
reported. In conclusion, adsorptive leukocytapheresis should
reduce corticosteroid therapy in patients with moderate UC;
cases with early-stage active disease may benefit most.
Publication Types: Clinical Trial
PMID: 15185858 [PubMed - indexed for MEDLINE]
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http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
Selective granulocyte and monocyte adsorptive apheresis as a
first-line treatment for steroid naive patients with active
ulcerative colitis: a prospective uncontrolled study.
Suzuki Y, Yoshimura N, Saniabadi AR, Saito Y.
Department of Internal Medicene, Sakura Hospital, Faculty of
Medicine, Toho University, 564-1 Shimoshizu, Sakura City,
Chiba 285-874, Japan. yasuo-suzuki@sakura.med.toho-u.ac.jp
Corticosteroid therapy of ulcerative colitis (UC) is
associated with frequent adverse side effects and poor
quality of life. Recently, adsorptive granulocyte and
monocyte/macrophage apheresis has shown efficacy in patients
with severe steroid refractory UC. The objective of this
study was to investigate if, instead of corticosteroids,
adsorptive leukocytapheresis has efficacy as the first-line
therapy for steroid-naive patients with active UC. Twenty
patients, aged 15-49 years, with a mean clinical activity
index (CAI) of 8.6 were recruited. Adsorptive
leukocytapheresis was done with Adacolumn, which contains
cellulose acetate beads as adsorptive carriers for
granulocytes and monocytes (FcgammaR and complement
receptors expressing leukocytes). Each patient received 6 to
10 leukocytapheresis sessions of 60-min duration, at 2
sessions/week. Efficacy was assessed 1 week after the last
session. Post treatment, the mean CAI was 3.0 (P = 0001),
and 17 of 20 patients (85%) were in remission. There were
significant falls in C-reactive protein (P = 0.0003), total
white cell counts (P = 0.003), neutrophils (P = 0.0029), and
monocytes (P
= .0038), an increase in lymphocytes (P = 0.001), and
= increases in the blood
levels of soluble TNF-alpha receptors I (P = 0.0007) and II
(P = 0.0045) in the column outflow (blood return to the
patients). Further, at 8 months, 60% of patients had
maintained their remission. No severe side effects were
reported. In conclusion, adsorptive leukocytapheresis should
reduce corticosteroid therapy in patients with moderate UC;
cases with early-stage active disease may benefit most.
Publication Types: Clinical Trial
PMID: 15185858 [PubMed - indexed for MEDLINE]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
