Doe
<<snip>> Immunologic factors probably play the crucial role
in the pathogenesis of paraneoplastic neurologic syndromes
Patients with paraneoplastic cerebellar degeneration present
with dizziness, nausea and vomiting followed by gait
instability, diplopia, gait and appendicular ataxia,
dysarthria and dysphagia.
neurologic status significantly improved after four daily
plasmaphereses <<snip>>
Acta Med Croatica. 2004;58(1):63-6. Related Articles, Links
[Importance of plasmapheresis in the treatment of
paraneoplastic cerebellar degeneration]
[Article in Croatian]
Basic-Jukic N, Kes P, Basic-Kes V, Brunetta B.
Zavod za dijalizu, Klinicki bolnicki centar Zagreb i
Klinika za neurologiju, Klinicka bolnica Sestre
milosrdnice, Zagreb, Hrvatska.
Paraneoplastic neurologic syndromes are disorders of the
nervous system function caused by cancer but not due to
metastatic disease, vascular or metabolic deficits,
infections, nutritive deficiency, nor side effects of
antineoplastic drugs or irradiation. Immunologic factors
probably play the crucial role in the pathogenesis of
paraneoplastic neurologic syndromes, but nonimmunologic
mechanisms that include metabolic abnormalities and
competition for substrate are also involved. Paraneoplastic
cerebellar degeneration most commonly occurs in the setting
of gynecologic cancers, but it accompanies the small-cell
lung cancer too. Other tumors are infrequently associated
with cerebellar degeneration. Several paraneoplastic
antibodies have been identified in patients with
paraneoplastic cerebellar degeneration. Their association
with particular cancers may help identify an occult lesion.
Anti-Yo antibodies are directed against Purkinje cell
antigens and occur in patients with cerebellar degeneration
who have breast cancer or gynecologic tumors. A target
antigen of anti-Yo antibody is CDR2 protein that is normally
expressed only in the brain and testis. Patients with
paraneoplastic cerebellar degeneration present with
dizziness, nausea and vomiting followed by gait instability,
diplopia, gait and appendicular ataxia, dysarthria and
dysphagia. Therapeutic options include tumor excision,
chemotherapy and/or irradiation, and adjuvant therapy with
glucocorticoids, immunoglobulins and plasmapheresis. The
role of plasmapheresis in the treatment of paraneoplastic
cerebellar degeneration is still uncertain. Reports of its
efficacy are anecdotal. We present patient with
paraneoplastic cerebellar degeneration with positive anti-Yo
antibodies and tumor of the ovaries whose neurologic status
significantly improved after four daily plasmaphereses,
which was accompanied by a fourfold decrease in the anti-Yo
antibodies titer. Further investigations are needed to
define a protocol for plasmapheresis in the treatment of
patients with paraneoplastic syndromes.
Publication Types: Case Reports
PMID: 15125396 [PubMed - indexed for MEDLINE]
------------------------------------------------------------
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------
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in the pathogenesis of paraneoplastic neurologic syndromes
Patients with paraneoplastic cerebellar degeneration present
with dizziness, nausea and vomiting followed by gait
instability, diplopia, gait and appendicular ataxia,
dysarthria and dysphagia.
neurologic status significantly improved after four daily
plasmaphereses <<snip>>
Acta Med Croatica. 2004;58(1):63-6. Related Articles, Links
[Importance of plasmapheresis in the treatment of
paraneoplastic cerebellar degeneration]
[Article in Croatian]
Basic-Jukic N, Kes P, Basic-Kes V, Brunetta B.
Zavod za dijalizu, Klinicki bolnicki centar Zagreb i
Klinika za neurologiju, Klinicka bolnica Sestre
milosrdnice, Zagreb, Hrvatska.
Paraneoplastic neurologic syndromes are disorders of the
nervous system function caused by cancer but not due to
metastatic disease, vascular or metabolic deficits,
infections, nutritive deficiency, nor side effects of
antineoplastic drugs or irradiation. Immunologic factors
probably play the crucial role in the pathogenesis of
paraneoplastic neurologic syndromes, but nonimmunologic
mechanisms that include metabolic abnormalities and
competition for substrate are also involved. Paraneoplastic
cerebellar degeneration most commonly occurs in the setting
of gynecologic cancers, but it accompanies the small-cell
lung cancer too. Other tumors are infrequently associated
with cerebellar degeneration. Several paraneoplastic
antibodies have been identified in patients with
paraneoplastic cerebellar degeneration. Their association
with particular cancers may help identify an occult lesion.
Anti-Yo antibodies are directed against Purkinje cell
antigens and occur in patients with cerebellar degeneration
who have breast cancer or gynecologic tumors. A target
antigen of anti-Yo antibody is CDR2 protein that is normally
expressed only in the brain and testis. Patients with
paraneoplastic cerebellar degeneration present with
dizziness, nausea and vomiting followed by gait instability,
diplopia, gait and appendicular ataxia, dysarthria and
dysphagia. Therapeutic options include tumor excision,
chemotherapy and/or irradiation, and adjuvant therapy with
glucocorticoids, immunoglobulins and plasmapheresis. The
role of plasmapheresis in the treatment of paraneoplastic
cerebellar degeneration is still uncertain. Reports of its
efficacy are anecdotal. We present patient with
paraneoplastic cerebellar degeneration with positive anti-Yo
antibodies and tumor of the ovaries whose neurologic status
significantly improved after four daily plasmaphereses,
which was accompanied by a fourfold decrease in the anti-Yo
antibodies titer. Further investigations are needed to
define a protocol for plasmapheresis in the treatment of
patients with paraneoplastic syndromes.
Publication Types: Case Reports
PMID: 15125396 [PubMed - indexed for MEDLINE]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
