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Thromb Res. 2004;113(6):345-51. Related Articles, Links
Vitamin E improves fibrinolytic activity in patients with
coronary spastic angina.
Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T,
Hokamaki J, Yoshimura M, Nakamura H, Yodoi J, Ogawa H.
Department of Cardiovascular Medicine, Graduate School of
Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto
860-8556, Japan.
Introduction: The fibrinolytic system has a major role as a
defense mechanism against thrombus formation. Net
fibrinolytic activity in plasma reflects the balance between
tissue-type plasminogen activator and plasminogen activator
inhibitor (PAI). PAI is the main factor determining overall
fibrinolytic activity. Materials and methods: We examined
the effects of oral administration of vitamin E, an
antioxidant, on fibrinolytic activity and oxidative stress
in patients with coronary spastic angina. Forty patients
with coronary spastic angina were randomly assigned into two
treatment groups, either vitamin E group (alpha-tocopherol
acetate, 400 mg/day) or placebo group by means of
computerized system. PAI activity and thioredoxin, a marker
of oxidative stress, levels were measured before and at the
end of 1 month treatment. Results: Before treatment, the
levels of PAI activity and thioredoxin were increased in
patients with coronary spastic angina as compared with
control subjects (n=17) (PAI activity levels: 13.6+/-1.4 vs.
7.6+/-2.2 IU/ml, p<0.05, thioredoxin levels: 22.8+/-1.7 vs.
16.0+/-1.4 ng/ml, p<0.05). In patients with coronary spastic
angina, administration of vitamin E decreased both PAI
activity and thioredoxin levels (PAI activity levels: 14.7+/-
1.7 to 7.5+/-1.6
IU/ml, p<0.01, thioredoxin levels: 23.3+/-2.4 to 15.1+/-2.5
ng/ml, p<0.01), whereas placebo had no effect on these
variables. Conclusions: Oral administration of vitamin E
improved fibrinolytic activity and the improvement was
associated with a decrease in oxidative stress.
Administration of vitamin E is possible to be an
effective adjunct therapy of coronary spasm in the
absence of coronary atherosclerosis.
PMID: 15226088 [PubMed - in process]
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http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
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Vitamin E improves fibrinolytic activity in patients with
coronary spastic angina.
Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T,
Hokamaki J, Yoshimura M, Nakamura H, Yodoi J, Ogawa H.
Department of Cardiovascular Medicine, Graduate School of
Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto
860-8556, Japan.
Introduction: The fibrinolytic system has a major role as a
defense mechanism against thrombus formation. Net
fibrinolytic activity in plasma reflects the balance between
tissue-type plasminogen activator and plasminogen activator
inhibitor (PAI). PAI is the main factor determining overall
fibrinolytic activity. Materials and methods: We examined
the effects of oral administration of vitamin E, an
antioxidant, on fibrinolytic activity and oxidative stress
in patients with coronary spastic angina. Forty patients
with coronary spastic angina were randomly assigned into two
treatment groups, either vitamin E group (alpha-tocopherol
acetate, 400 mg/day) or placebo group by means of
computerized system. PAI activity and thioredoxin, a marker
of oxidative stress, levels were measured before and at the
end of 1 month treatment. Results: Before treatment, the
levels of PAI activity and thioredoxin were increased in
patients with coronary spastic angina as compared with
control subjects (n=17) (PAI activity levels: 13.6+/-1.4 vs.
7.6+/-2.2 IU/ml, p<0.05, thioredoxin levels: 22.8+/-1.7 vs.
16.0+/-1.4 ng/ml, p<0.05). In patients with coronary spastic
angina, administration of vitamin E decreased both PAI
activity and thioredoxin levels (PAI activity levels: 14.7+/-
1.7 to 7.5+/-1.6
IU/ml, p<0.01, thioredoxin levels: 23.3+/-2.4 to 15.1+/-2.5
ng/ml, p<0.01), whereas placebo had no effect on these
variables. Conclusions: Oral administration of vitamin E
improved fibrinolytic activity and the improvement was
associated with a decrease in oxidative stress.
Administration of vitamin E is possible to be an
effective adjunct therapy of coronary spasm in the
absence of coronary atherosclerosis.
PMID: 15226088 [PubMed - in process]
------------------------------------------------------------
--------------
------
Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com (http://jesuswasavegetarian.7h.com/) Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
