Armstrong's DNA

B. Lafferty

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Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But = will Lance say thank you to
the "DNA donor" who is his biological = father?

Brian--accept no substitutes--Lafferty Dear, you cannot drink gin and tonic in the middle of the
night.=20 You must have whisky to give you energy. --Margaret Thatcher
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<DIV><FONT face=3D"Comic Sans MS" size=3D2>Ah, the irony.  Lance's = Subaru=20 commercial
tells us it's in the DNA.  But will Lance say thank = you to=20 the "DNA donor" who
is his biological father?</FONT></DIV>
<DV><FONT face=3D"Comic Sans MS" size=3D2></FONT> </DIV>
<DVI><FONT face=3D"Comic Sans MS" size=3D2>Brian--accept no=20 substitutes--Lafferty</FONT></DIV>
<DVII><FONT size=3D2>Dear, you cannot drink gin and tonic in the middle = of the=20 night. <BR>You
must have whisky to give you energy.<BR>--Margaret=20 Thatcher</FONT></DIV></BODY></HTML>

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Andy Coggan

"B. Lafferty" <nospam@hotmail.com> wrote in message
news:z%6xa.328$rO.53670@newsread1.prod.itd.earthlink.net...

> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
will Lance say thank you to the "DNA donor" who is his biological father?

Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.

Andy Coggan

Amh

"B. Lafferty" <nospam@hotmail.com> wrote in message
news:<z%6xa.328$rO.53670@newsread1.prod.itd.earthlink.net>...
> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But will Lance say thank you to
> the "DNA donor" who is his biological father?

He said "thank you" to the guy who gave him his Subaru paycheck though.

Andy

>
> Brian--accept no substitutes--Lafferty Dear, you cannot drink gin and tonic in the middle of the
> night. You must have whisky to give you energy. --Margaret Thatcher
> --

Sam

Damn, beat me to it!

"Andy Coggan" <acoggan@earthlink.net> wrote in message
news:vF7xa.360$rO.56141@newsread1.prod.itd.earthlink.net...
> "B. Lafferty" <nospam@hotmail.com> wrote in message
> news:z%6xa.328$rO.53670@newsread1.prod.itd.earthlink.net...
>
> > Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
> will Lance say thank you to the "DNA donor" who is his biological father?
>
>
> Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
>
> Andy Coggan

Kyle Legate

Andy Coggan wrote:
> "B. Lafferty" <nospam@hotmail.com> wrote in message
> news:z%6xa.328$rO.53670@newsread1.prod.itd.earthlink.net...
>
>> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
> will Lance say thank you to the "DNA donor" who is his biological father?
>
>
> Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
>
Most mitochondrial proteins are encoded by nuclear DNA.

Andy Coggan

"Kyle Legate" <legatek@sympatico.ca> wrote in message
news:89exa.6759$I83.917161@news20.bellglobal.com...
> Andy Coggan wrote:
> > "B. Lafferty" <nospam@hotmail.com> wrote in message
> > news:z%6xa.328$rO.53670@newsread1.prod.itd.earthlink.net...
> >
> >> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
> > will Lance say thank you to the "DNA donor" who is his biological father?
> >
> >
> > Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
> >
> Most mitochondrial proteins are encoded by nuclear DNA.

True. But w/o the mitochondrial contribution, you can't make properly functioning
mitochondria...hence (apparently) the presence of "ragged red fibers" in certain neuromuscular
diseases, in the elderly, in peripheral vascular disease, etc.

Andy Coggan

Kyle Legate

Andy Coggan wrote:
> "Kyle Legate" <legatek@sympatico.ca> wrote in message
> news:89exa.6759$I83.917161@news20.bellglobal.com...
>>>
>> Most mitochondrial proteins are encoded by nuclear DNA.
>
> True. But w/o the mitochondrial contribution, you can't make properly functioning
> mitochondria...hence (apparently) the presence of "ragged red fibers" in certain neuromuscular
> diseases, in the elderly, in peripheral vascular disease, etc.
>
Of course both genetic contributions are crucial for properly functioning mitochondria, but without
the nuclear component mice don't even make it to birth.

eg,

Chen et al, Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential
for embryonic development. J Cell Biol. 2003 Jan 20;160(2):189-200.

Di Pietro et al, Mitochondrial NAD-dependent methylenetetrahydrofolate
dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development. Mol
Cell Biol. 2002 Jun;22(12):4158-66.

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