PDA

View Full Version : syncope with hctz













Bill
  
Quick question for the group
I'm a 34 general surgery resident with recently dx'd essential
hypertension. I started Prinivil and worked up to a dose of 40 mg qd
without marginal results in lowering BP (150/90). I went a saw a GP
that I thought was fairly knowledgable with current BP treatments (j7,
etc.) and started taking HCTZ 25mg daily. I lasted 5 days and had 2
syncopal episodes one morning about 3 hours after taking the
medication. Had orthostatic BP's taken about 1 hour after episode and
ssupine was 134/74 and standing 115/53.
I don't want to sound uninformed by BP regulation in a thirty yo white
male is definetly not my specality but I have a few questions.
I underwent a basic workup after the syncope (EEG,CT, Cartoids, Trop I
, CPK's, EKG) and all normal. Labs were normal as well. I orginally
thought I was dehydrated but Bun was only 17 and creat normal. Lytes
were WNL as well. So I assume this was hypotensive in nature but a few
things perplex me.
IN the mean time I've stopped the HCTZ and continue the Prinivl at 40
mg but still too high again. (138/85 thur 160/95).
To say the least I'm a little gun shy at starting the HCTZ again.
Syncope in a resident, definetly not a good thing.

I've reviewed the J7 document( which I beleive is the most current)
regarding anithypertensive regs.

Is Prinivil 40 and HCTZ 25 too much?? Is syncope common with this
dosage?
Should I try Prinivil 10 and maybe HCTZ 6.25. Just wondering, do you
guys ever see syncope with a low dose such as this?

Appreciate any input from the collective. Thanks in advance. Bill

Dr. Andrew B. Chung, MD/PhD
  
Bill wrote:

> Quick question for the group
> I'm a 34 general surgery resident with recently dx'd essential
> hypertension. I started Prinivil and worked up to a dose of 40 mg qd
> without marginal results in lowering BP (150/90). I went a saw a GP
> that I thought was fairly knowledgable with current BP treatments (j7,
> etc.) and started taking HCTZ 25mg daily. I lasted 5 days and had 2
> syncopal episodes one morning about 3 hours after taking the
> medication. Had orthostatic BP's taken about 1 hour after episode and
> ssupine was 134/74 and standing 115/53.
> I don't want to sound uninformed by BP regulation in a thirty yo white
> male is definetly not my specality but I have a few questions.
> I underwent a basic workup after the syncope (EEG,CT, Cartoids, Trop I
> , CPK's, EKG) and all normal. Labs were normal as well. I orginally
> thought I was dehydrated but Bun was only 17 and creat normal. Lytes
> were WNL as well. So I assume this was hypotensive in nature but a few
> things perplex me.
> IN the mean time I've stopped the HCTZ and continue the Prinivl at 40
> mg but still too high again. (138/85 thur 160/95).
> To say the least I'm a little gun shy at starting the HCTZ again.
> Syncope in a resident, definetly not a good thing.
>
> I've reviewed the J7 document( which I beleive is the most current)
> regarding anithypertensive regs.
>
> Is Prinivil 40 and HCTZ 25 too much??

Sounds like it for you.

> Is syncope common with this
> dosage?

No (in folks who don't become orthostatic).

>
> Should I try Prinivil 10 and maybe HCTZ 6.25. Just wondering, do you
> guys ever see syncope with a low dose such as this?
>

Would suggest asking your GP about starting off with HCTZ at 25 mg and
then titrating up the Prinivil as tolerated (ie no orthostasis).

>
> Appreciate any input from the collective. Thanks in advance. Bill

"the collective" ? Sounds "Borg"ish (ala Nextgen) to me :-)

You are welcome nonetheless.

Humbly,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com/

Bulgarian Croatian Czech Danish Dutch English Finnish French German Italian Japanese Korean Norwegian Polish Portuguese Spanish Swedish