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Re: Effects of Atorvastatin on vitamin D levels in patients

View Full Version : Re: Effects of Atorvastatin on vitamin D levels in patients




Andrew B. Chung, MD/PhD
  
tedhutchinson wrote:
> Andrew, in the Holy Spirit, boldly wrote:
> > William Wagner wrote:
> > > A small study butDand K keep on showing up.
> >
> > > Bill
> >
> > > "atorvastatin increasesvitaminDlevels. This increase could explain
> > > some of the beneficial effects of atorvastatin at the cardiovascular
> > > level that are unrelated to cholesterol levels."
> >
> > > Yea but Bill who can't handle statins reads this asDmay be good to
> > > increase. Sun and supplements.
> > > ...............................
> >
> > > Am J Cardiol. 2007 Apr 1;99(7):903-5. Epub 2007 Feb 8.
> >
> > > Effects of Atorvastatin onvitaminDlevels in patients with acute
> > > ischemic heart disease.
> > > Pérez-Castrillón JL, Vega G, Abad L, Sanz A, Chaves J, Hernandez G,
> > > Dueñas A.
> >
> > > Internal Medicine Department, Río Hortega University Hospital, Faculty
> > > of Medicine of Valladolid, Valladolid, Spain. cas...@terra.es
> > >VitaminDdeficiency is a risk factor for osteoporosis and other chronic
> > > diseases, including type 1 diabetes, hypertension, metabolic syndrome,
> > > and ischemic heart disease. Cholesterol andvitaminDshare the
> > > 7-dehydrocholesterol metabolic pathway. This study evaluated the
> > > possible effect of atorvastatin onvitaminDlevels in patients with
> > > acute ischemic heart disease. Eighty-three patients (52 men and 31
> > > women) with an acute coronary syndrome (75 with acute myocardial
> > > infarction and 8 with unstable angina) were included. After diagnosis,
> > > patients received atorvastatin as secondary prevention. SerumvitaminD
> > > was measured by high-performance liquid chromatography at baseline and
> > > at 12 months. Atorvastatin treatment produced a statistically
> > > significant decrease in cholesterol and triglyceride levels and an
> > > increase invitaminDlevels (41+/-19 vs 47+/-19 nmol/L, p=0.003).
> > >VitaminDdeficiency was decreased by 75% to 57% at 12 months. In
> > > conclusion, atorvastatin increasesvitaminDlevels. This increase could
> > > explain some of the beneficial effects of atorvastatin at the
> > > cardiovascular level that are unrelated to cholesterol levels.
> > > PMID: 17398180 [PubMed - indexed for MEDLINE]
> >
> > Hopefully folks won't be compelled to go overboard onvitaminD
> > supplementation after reading this.
> >
> > There are those who are getting plenty of sun who might reach toxic
> > levels when takingvitaminDsupplements.
> >
> > Someone who is less healthy because of being deficient invitaminD
> > will become hungrier with repletion as they become healthier.
> >
> > Toxicity will cause a reduction in appetite as there is a concomitant
> > reduction in health.
>
> Those who are concerned about the safety of Vitamin d3 supplementation
> may be interested in reading the latest research findings at
> Risk Assessment Vitamin D
> http://www.ajcn.org/cgi/content/abstract/85/1/6 where they present a
> risk assessment based on relevant, well-designed human clinical trials
> of vitamin D. Collectively, the absence of toxicity in trials
> conducted in healthy adults that used vitamin D dose 250 µg/d (10 000
> IU vitamin D3) supports the confident selection of this value as the
> Upper Limit.
>
> Anyone who finds reading scientific papers rather hard going may
> prefer to listen/watch Vieth going over much the same ground in this
> 20minute presentation
> http://app2.capitalreach.com/esp1204/servlet/tc?cn=asbmr&c=10169&s=20343&e=6950&&
> session4 Vitamin D and Population Health use the arrows by the slide
> preview to fast forward to slide 61 the slide you really need to pay
> attention to is slide 76. The points you need to bear in mind is that
> 4000iu/d is the amount your body actually uses daily. You cannot
> overdose on Vitamin D from sunshine. The amount of vitamin D your body
> creates in any day's sunbathing is 10,000iu and this is the natural
> maximum amount is the one they select as the safe upper limit given
> that actual physical harm occurs only after 40,000iu/daily has been
> consumed daily for some time.
> The point of mentioning this is that one has to be fairly determined
> to use Cholecalciferol and sunbathing. It's hard work for most people
> raising nmol/L status to 125nmol/L so raising it to the 500nmol/L
> necessary to cause hypercalcemia is going to take an extraordinary
> level of supplementation with D3.

We live in an accursed world where anything than can go wrong does:

http://SecondLaw.com

Be hungry... be healthy... be blessed:

http://HeartMDPhD.com/Press.asp

Prayerfully in Jesus' awesome love,

Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist

percy
  
Andrew B. Chung, MD/PhD wrote:
> tedhutchinson wrote:
>> Andrew, in the Holy Spirit, boldly wrote:
>>> William Wagner wrote:
>>>> A small study butDand K keep on showing up.
>>>> Bill
>>>> "atorvastatin increasesvitaminDlevels. This increase could explain
>>>> some of the beneficial effects of atorvastatin at the cardiovascular
>>>> level that are unrelated to cholesterol levels."
>>>> Yea but Bill who can't handle statins reads this asDmay be good to
>>>> increase. Sun and supplements.
>>>> ...............................
>>>> Am J Cardiol. 2007 Apr 1;99(7):903-5. Epub 2007 Feb 8.
>>>> Effects of Atorvastatin onvitaminDlevels in patients with acute
>>>> ischemic heart disease.
>>>> Pérez-Castrillón JL, Vega G, Abad L, Sanz A, Chaves J, Hernandez G,
>>>> Dueñas A.
>>>> Internal Medicine Department, Río Hortega University Hospital, Faculty
>>>> of Medicine of Valladolid, Valladolid, Spain. cas...@terra.es
>>>> VitaminDdeficiency is a risk factor for osteoporosis and other chronic
>>>> diseases, including type 1 diabetes, hypertension, metabolic syndrome,
>>>> and ischemic heart disease. Cholesterol andvitaminDshare the
>>>> 7-dehydrocholesterol metabolic pathway. This study evaluated the
>>>> possible effect of atorvastatin onvitaminDlevels in patients with
>>>> acute ischemic heart disease. Eighty-three patients (52 men and 31
>>>> women) with an acute coronary syndrome (75 with acute myocardial
>>>> infarction and 8 with unstable angina) were included. After diagnosis,
>>>> patients received atorvastatin as secondary prevention. SerumvitaminD
>>>> was measured by high-performance liquid chromatography at baseline and
>>>> at 12 months. Atorvastatin treatment produced a statistically
>>>> significant decrease in cholesterol and triglyceride levels and an
>>>> increase invitaminDlevels (41+/-19 vs 47+/-19 nmol/L, p=0.003).
>>>> VitaminDdeficiency was decreased by 75% to 57% at 12 months. In
>>>> conclusion, atorvastatin increasesvitaminDlevels. This increase could
>>>> explain some of the beneficial effects of atorvastatin at the
>>>> cardiovascular level that are unrelated to cholesterol levels.
>>>> PMID: 17398180 [PubMed - indexed for MEDLINE]
>>> Hopefully folks won't be compelled to go overboard onvitaminD
>>> supplementation after reading this.
>>>
>>> There are those who are getting plenty of sun who might reach toxic
>>> levels when takingvitaminDsupplements.
>>>
>>> Someone who is less healthy because of being deficient invitaminD
>>> will become hungrier with repletion as they become healthier.
>>>
>>> Toxicity will cause a reduction in appetite as there is a concomitant
>>> reduction in health.
>> Those who are concerned about the safety of Vitamin d3 supplementation
>> may be interested in reading the latest research findings at
>> Risk Assessment Vitamin D
>> http://www.ajcn.org/cgi/content/abstract/85/1/6 where they present a
>> risk assessment based on relevant, well-designed human clinical trials
>> of vitamin D. Collectively, the absence of toxicity in trials
>> conducted in healthy adults that used vitamin D dose 250 µg/d (10 000
>> IU vitamin D3) supports the confident selection of this value as the
>> Upper Limit.
>>
>> Anyone who finds reading scientific papers rather hard going may
>> prefer to listen/watch Vieth going over much the same ground in this
>> 20minute presentation
>> http://app2.capitalreach.com/esp1204/servlet/tc?cn=asbmr&c=10169&s=20343&e=6950&&
>> session4 Vitamin D and Population Health use the arrows by the slide
>> preview to fast forward to slide 61 the slide you really need to pay
>> attention to is slide 76. The points you need to bear in mind is that
>> 4000iu/d is the amount your body actually uses daily. You cannot
>> overdose on Vitamin D from sunshine. The amount of vitamin D your body
>> creates in any day's sunbathing is 10,000iu and this is the natural
>> maximum amount is the one they select as the safe upper limit given
>> that actual physical harm occurs only after 40,000iu/daily has been
>> consumed daily for some time.
>> The point of mentioning this is that one has to be fairly determined
>> to use Cholecalciferol and sunbathing. It's hard work for most people
>> raising nmol/L status to 125nmol/L so raising it to the 500nmol/L
>> necessary to cause hypercalcemia is going to take an extraordinary
>> level of supplementation with D3.
>
> We live in an accursed world where anything than can go wrong does:
>
> http://SecondLaw.com
>
> Be hungry... be healthy... be blessed:
>
> http://HeartMDPhD.com/Press.asp
>
> Prayerfully in Jesus' awesome love,
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhD
> Cardiologist
>

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