Re: Bisphosphonates and Drug-resistant Microbes

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>> On Jul 11, 4:15 pm, ironjustice <teamtan...@hotmail.com> wrote:
On Jul 8, 11:30 am, ironjustice <teamtan...@hotmail.com> wrote:
Sooo .. IS .. this simply .. vegetable lecithin .. ? <<

Immunology. 1998 May;94(1):35-40. Related Articles, Links


Immunization of mice with phosphatidylcholine drastically reduces the
parasitaemia of subsequent Plasmodium chabaudi chabaudi blood-stage
infections.

Bordmann G, Rudin W, Favre N.

Department of Medical Parasitology, Swiss Tropical Institute, Basel,
Switzerland.

It has been suggested that phospholipids and antibodies directed
against phospholipids are important in the pathology of malaria. We
have investigated the influence of immunizations with phospholipids on
the course of subsequent blood-stage Plasmodium chabaudi chabaudi
infections in ICR inbred mice. We observed a significant reduction in
the parasitaemia following immunization with phosphatidylcholine (PC),
but not with phosphatidylethanolamine (PE) immunization. At the peak
of the infection, PC-immunized mice displayed a T-helper 2 (Th2)-type
cytokine production pattern, whereas PE-immunized or non-treated
controls displayed a cytokine production pattern of the T-helper 1
(Th1) type. Serum immunoglobulin transfer from PC-immunized mice
protected naive mice in a similar fashion to PC-immunization,
demonstrating that the observed reduction of parasitaemia was caused
by the presence of PC-specific antibodies.

PMID: 9708184 [PubMed - indexed for MEDLINE]

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