Something's .. fishy ..?

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Br J Nutr 2003 Jan;89(1):11-8

Effects of fish oil- and olive oil-rich diets on iron metabolism and oxidative stress in the rat.

Miret S, Saiz MP, Mitjavila MT Departament de Fisiologia, Facultat de Biologia, Universitat de
Barcelona, Avda. Diagonal, 645, 08028 Barcelona, Spain.

[Medline record in process]

The objective of the present study was to examine the effects of fish oil (FO)- and olive oil
(OO)-rich diets on Fe metabolism and oxidative stress. Rats were fed for 16 weeks with diets
containing 50 g lipids/kg; either OO, maize oil (MO) or FO. OO or MO diets contained a standard
amount (100 mg/kg) of all-rac-alpha-tocopheryl acetate. FO diets were supplemented with 0, 100 or
200 mg all-rac-alpha-tocopheryl acetate/kg (FO-0, FO-1 or FO-2 diets, respectively). At the end of
the feeding period, we measured non-haem Fe stores in liver and spleen, and erythrocyte and
reticulocyte count. We also determined antioxidants and products derived from lipid peroxidation in
plasma and erythrocytes. Our results showed reduced non-haem Fe stores in rats fed any of the FO
diets. Reticulocyte percentage was higher in the rats fed FO-0 and FO-1. Plasma alpha-tocopherol was
very low in rats fed the FO-0 diet. Rats fed the FO-1 and FO-2 diets showed higher alpha-tocopherol
in plasma than the FO-0 group but lower than the MO or OO groups. We did not observe such
differences in the alpha-tocopherol content in erythrocyte membranes. Superoxide dismutase and
glutathione peroxidase activities were lower in the erythrocytes of rats fed the FO-0 diet. The
products derived from lipid peroxidation were also higher in the FO groups. The administration of
FO-rich diets increased lipid peroxidation and affected Fe metabolism. On the other hand, the
OO-rich diet did not increase oxidative stress and did not alter Fe metabolism. Based on these
results, we conclude that FO supplementation should be advised carefully.

PMID: 12568660, UI: 22456291

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