antioxidants / oxidative stress / panic disorder

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This may give some credence to the 'iron theory' of panic / anxiety cause due to the fact IP6 /
phytic acid has shown some benefit and it is a natural iron binder .. therefore .. an antioxidant.

Neuropsychobiology 2002;46(4):186-9

Antioxidant enzyme and malondialdehyde levels in patients with panic disorder.

Kuloglu M, Atmaca M, Tezcan E, Ustundag B, Bulut S Department of Psychiatry, Medical Faculty, Firat
University, Elazig, Turkey.

[Medline record in process]

There is evidence of an etiopathogenetic role of free radicals (FRs) in some neuropsychiatric
disorders. The aim of the present study was to determine whether the activity levels of some
antioxidant enzymes [glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT)]
and malondialdehyde (MDA), a product of lipid peroxidation, were associated with panic disorder
(PD). Twenty patients diagnosed with PD and 20 healthy controls were enrolled in this study. A
clinical evaluation and measurements of GSH-Px SOD, CAT and MDA were performed. Additionally, all
patients were assessed by the Panic Agoraphobia Scale (PAS). The mean GSH-Px, SOD and MDA levels of
the patient group were significantly higher than those of the controls. There was a significant
positive correlation between PAS scores and GSH-Px, SOD and MDA levels and between the duration of
illness and SOD, CAT and MDA levels in the patient group. In conclusion, our results suggest that
FRs may be involved in PD. Copyright 2003 S. Karger AG, Basel

PMID: 12566935, UI: 22454524

Who loves ya. Tom

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