Any recommendations on supplements to improve skin tone/reduce wrinkles?

Do supplements really help improve collagen and elastin structure? TIA

Yes!

Get some omega 3s such as fish oil or flaxseed oil.

HTH

Trent

-- Look and Feel Great! FREE weight loss and anti-aging group. Join now @
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> From: xwibbiex3@yahoo.com (xwibbie) Organization: http://groups.google.com Newsgroups:
> sci.med.nutrition Date: 23 Oct 2003 09:38:36 -0700 Subject: Any recommendations on supplements to
> improve skin tone/reduce wrinkles?
>
> Do supplements really help improve collagen and elastin structure? TIA

"xwibbie" <xwibbiex3@yahoo.com> wrote in message
news:63d95834.0310230838.3f1162b9@posting.google.com...
> Do supplements really help improve collagen and elastin structure? TIA

Orals that impart a significant change to the skin's structure or function require a prescription.
People who wish to sell you something might say otherwise.

HRT and the fish thingy promote hydration and oil production, creating the illusion of a fuller,
plumper skin. If the underlying support structures are severely damaged, there will be very little,
if any, real alteration. In that case, there is not much of an alternative to removing the damaged
layer, or using a very strong topical retinoid on a long-term basis, which might in some cases
approach the results of a TCA peel if used consistently and aggressively.

If you already eat fatty fish on a regular basis, I doubt that you will notice anything by taking a
(very expensive Finnish) fish oral.

The oral retinoid is likely to do much more than that. Your best bet is probably a topical,
though--tretinoin or tazarotene, because systemic effects are minimal compard to oral isotretinoin.

---------------------------------

Maturitas. 2001 Jul 25;39(1):43-55. The influence of hormone replacement therapy on skin ageing: a
pilot study. Sator PG, Schmidt JB, Sator MO, Huber JC, Honigsmann H. Department of Special and
Environmental Dermatology, University of Vienna, General Hospital, Wahringer Gurtel 18-20, 1090
Vienna, Austria.

OBJECTIVES: We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:
Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6
months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm
TTS 50) (n=6); 2, transdermal oestrogen and progesterone (Estraderm TTS 50 and 0.4 mg progesterone
vaginal suppository) (n=7); and 3, oral oestrogen and progesterone (2 mg Progynova and 0.4 mg
progesterone vaginal suppository) (n=8). One group without therapy was included as a control group
(n=3). Treatment was continued for 6 months. Three patients, one from group 2 and two from group 3,
discontinued therapy before the study endpoint. The following skin parameters were measured at
monthly intervals during treatment: skin surface lipids, epidermal skin hydration, skin elasticity
and skin thickness. Concomitant clinical evaluation included a subjective clinical evaluation form,
a patient questionnaire and laboratory tests for oestradiol, progesterone and follicle stimulating
hormone. RESULTS: Mean levels of epidermal skin moisture, elasticity and skin thickness were
improved at the end of treatment based on both subjective and objective evaluation in patients with
hormone replacement therapy (HRT). Skin surface lipids were increased during combined HRT, which may
reflect stimulatory effects of the progestagen component on sebaceous gland activity, while
oestrogen alone has a sebum-suppressive action. In the HRT groups, the questionnaire for climacteric
complaints demonstrated significant improvements, while laboratory tests showed increases in
oestradiol and progesterone and decreases in FSH. CONCLUSIONS: HRT with the mentioned regimes
significantly improved parameters of skin ageing.

Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 11451620 [PubMed - indexed for MEDLINE]

Dermatol Surg. 2000 Jul;26(7):649-52. Oral isotretinoin as part of the treatment of cutaneous aging.
Hernandez-Perez E, Khawaja HA, Alvarez TY. Center for Dermatology and Cosmetic Surgery, San
Salvador, El Salvador. enrimar@ejje.com

BACKGROUND: A number of drugs have been used to prevent aging changes. However, studies of oral
isotretinoin, the commonly used acne drug, as an antiaging drug are lacking. OBJECTIVE: To determine
improvement in cutaneous aging utilizing oral isotretinoin combined with different procedures of
facial rejuvenation. METHODS: Sixty patients ranging in age from 35 to 65 years, in whom additional
modalities of rejuvenation were also used, were randomly assigned to receive treatment with oral
isotretinoin (10-20 mg three times a week for 2 months, group A). Their results were compared with
60 patients who had undergone the same surgical procedures but with no oral isotretinoin (group B).
RESULTS: All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and
color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and
mottled hyperpigmentation. A statistically significant difference was found in the improvement of
group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically
negligible. CONCLUSION: Utilizing various procedures with oral isotretinoin allowed us to improve
the effects of cutaneous aging. Our results using isotretinoin in these cases have been
satisfactory. We believe that this is one of the first reports of the use of oral isotretinoin in
intrinsic and photoaged skin.

Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 10886272 [PubMed - indexed for MEDLINE]

Maturitas. 1999 Jun 21;32(2):87-93. Climacteric skin ageing of the face--a prospective longitudinal
comparative trial on the effect of oral hormone replacement therapy. Pierard-Franchimont C, Cornil
F, Dehavay J, Deleixhe-Mauhin F, Letot B, Pierard GE. Department of Dermatopathology, Belgian SSTC
Research Center 5596, University Medical Center Sart Tilman, Liege.

BACKGROUND: It is still a matter of debate whether HRT improves the physical quality of sun damaged
skin. OBJECTIVES: To compare in a prospective longitudinal study the effects of climacteric aging
controlled or not by HRT upon the tensile properties of facial skin. METHOD: A total of 140 women
aged 40-52 years were enrolled in the study. The HRT group comprised 90 volunteers and a control
group encompassed 50 non recipient volunteers. Yearly measurements of tensile functions of facial
skin were performed for 5 years. A computerized suction device equipped with a 2-mm diameter hollow
probe derived tensile variables quantifying skin distensibility, viscosity and elasticity. RESULTS:
Climacteric aging was characterized by increased skin distensibility (1.1% per year) and viscosity
(1.3% per year) mirrored by a decrease in elasticity (1.5% per year). HRT helped mitigate such
changes. However, the HRT efficacy was not similar in all volunteers. Groups of good and poor
responders were clearly identified as far as benefit on skin elasticity was concerned. CONCLUSION:
The beneficial effect of HRT upon climacteric skin aging of the face is confirmed, at least in a
subgroup of menopausal women.

Publication Types: Clinical Trial Controlled Clinical Trial

PMID: 10465376 [PubMed - indexed for MEDLINE]

J Int Med Res. 1992 Jun;20(3):273-8. An oral approach to the treatment of photodamaged skin: a pilot
study. Heule F. Department of Dermatology and Venereology, Academic Hospital Rotterdam-Dijkzigt,
Netherlands.

In recent publications much attention has focused on skin changes as a consequence of ageing. During
life many internal and external factors have an influence on the condition of the skin but
ultraviolet radiation seems to be a major factor in both benign and malignant alterations. To retard
the deterioration process, more than cosmetic concern is necessary. In a pilot study, a fish protein
product is shown to have the capacity to ameliorate, both objectively and subjectively, the symptoms
of photo-aged skin. Recommendations are made for further evaluation.

PMID: 1397672 [PubMed - indexed for MEDLINE]

J Int Med Res. 1992 Apr;20(2):99-105. Special natural cartilage polysaccharides for the treatment
of sun-damaged skin in females. Eskelinin A, Santalahti J. Department for Dermatological Research,
ARS-Medicina, Helsinki, Finland.

In the present double-blind investigation, the effects of a new formulation of natural cartilage
polysaccharides on sundamaged skin were studied in women aged 40-60 years. A group of 15 women were
treated orally with 500 mg/day active substance (Vivida) for 90 days and a second group of 15 women
received 500
mg/day placebo for 90 days. Clinical examinations after 45 and 90 days' treatment showed significant
improvements in skin condition in the actively treated group but not in the placebo group (P less
than 0.001). In the Vivida-treated patients, the epidermal thickness increased after 90 days from
.11 mm to 0.29 mm, dermal thickness from 0.74 mm to 1.39 mm, skin elasticity index from 44% to
73% and the erythemal index decreased from 0.301 to 0.205. No changes were observed in the
placebo group and no adverse effects were reported by either treatment group.

Publication Types: Clinical Trial Controlled Clinical Trial Randomized Controlled Trial

PMID: 1521676 [PubMed - indexed for MEDLINE]

J Int Med Res. 1991 Mar-Apr;19(2):147-52. Imedeen for the treatment of degenerated skin in females.
Lassus A, Jeskanen L, Happonen HP, Santalahti J. Department of Dermatology, University Central
Hospital, Helsinki, Finland.

Imedeen, a new compound for oral administration consisting of special protein fractions and some
glucosaminoglycans extracted from marine fish, has been shown in previous pilot studies to have a
repairing effect on sun-damaged skin. In an open study, 10 females with sun-damaged skin, aged 39-61
years, were treated with 0.5 g/day Imedeen for 90 days. At baseline and after 30, 60 and 90 days,
the following parameters were clinically evaluated: wrinkles; mottles; dryness of skin; and
brittleness of hair and nails. After 90 days' treatment all signs of sun-damage had improved and
brittleness of hair and nails was normalized in all cases. These clinical observations were
confirmed by changes in skin thickness and elasticity. In a second double-blind study, 30 females in
the same age range and with similar signs of sun-damage were treated with 0.5 g/day Imedeen or
placebo for 90 days. The results in the Imedeen-treated group corresponded to those in the first
study whereas no response to treatment was observed in the placebo treatment group.

Publication Types: Clinical Trial Randomized Controlled Trial

PMID: 1864451 [PubMed - indexed for MEDLINE]

On 23 Oct 2003 09:38:36 -0700, xwibbiex3@yahoo.com (xwibbie) posted:

>Do supplements really help improve collagen and elastin structure? TIA

Not above a good diet. If you are ill or deficient in some nutrient, then supplementing for these
might help. See your medical advisor.

"xwibbie" <xwibbiex3@yahoo.com> wrote in message
news:63d95834.0310230838.3f1162b9@posting.google.com...

> Do supplements really help improve collagen and elastin structure? TIA

Look at those chemicals that slow the cross-linking of collagen and elastin. B-6, B-6 in the
amine form, B-2 and its analog, Alt-711, carnosine, and a-lipoic acid. Use supra-nutritional
levels otherwise you'll end up looking like the wrinkled gray torus shaped Moo-She sooner rather
than later.

Stay out of the midday sun and take a good vitamin D supplement.

Giselle posting was good.

"Moosh!" <less@even.less> wrote in message news:agdhpv4t2q0eof3hcl8mddoce8bao12kpq@4ax.com...
> On 23 Oct 2003 09:38:36 -0700, xwibbiex3@yahoo.com (xwibbie) posted:
>
> >Do supplements really help improve collagen and elastin structure? TIA
>
> Not above a good diet. If you are ill or deficient in some nutrient, then supplementing for these
> might help. See your medical advisor.

Yeah, right go to an over-worked GP with a whole minute to see you and to worry about something he
knows nothing about and is not trained to deal with.

On Thu, 23 Oct 2003 23:16:48 -0700, "William A. Noyes" <no.address@ctc.net> posted:

>
>"Moosh!" <less@even.less> wrote in message news:agdhpv4t2q0eof3hcl8mddoce8bao12kpq@4ax.com...
>> On 23 Oct 2003 09:38:36 -0700, xwibbiex3@yahoo.com (xwibbie) posted:
>>
>> >Do supplements really help improve collagen and elastin structure? TIA
>>
>> Not above a good diet. If you are ill or deficient in some nutrient, then supplementing for these
>> might help. See your medical advisor.
>
>Yeah, right go to an over-worked GP with a whole minute to see you and to worry about something he
>knows nothing about and is not trained to deal with.

Who are you talking about? Certainly not any doc I have consulted. Although once I had an
unsatifactory consult, so changed doctor. You appear to be a poor consumer. Maybe it's those
unsatisfactory elected regulators who create your very bad health system.