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Merck took out a patent on coenzyme q10 (in conjunction with
statins) in 1989. This was 10 years before the 100+ deaths
caused by Baycol rhabdomyolysis. Since then of course, there
have been many more statin deaths from rhabdomyolysis (most
notably from lipitor and crestor.)

US Patents: # 4,933,165 http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/sr-
chnum.htm&r=1&f=G&l=50&s1=4933165.WKU.&OS=PN/4933165&RS=-
PN/4933165

see also subsequent related patents: Do a search by patent
number at: http://patft.uspto.gov/netahtml/srchnum.htm for
the following: United States Patent 5,082,650 United States
Patent 5,849,777 United States Patent 6,264,960 Merck Patent
application stating that statins interfere with CoQ10 and
that deficiency causes problems. They documented that they
knew this about statins in 1989, 10 years before the 100+
deaths by rhabdomyolysis.
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Petition to the FDA to issue strong warnings about the
potential for certain cholesterol-lowering drugs to cause
potentially life-threatening muscle damage. (HRG Publication
#1588) (hide summary) http://www.publiccitizen.org/publicat-
ions/release.cfm?ID=7051
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Petition to the FDA to remove the cholesterol-lowering drug
rosuvastatin (CRESTOR) from the market (HRG Publication
#1693) http://www.publiccitizen.org/publications/release.c-
fm?ID=7305
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Public Citizen Warns Against New Statin Drug Crestor
Cholesterol Drug Potentially More Dangerous Than Baycol; FDA
Should Not Have Allowed on Market
http://www.publiccitizen.org/pressro...se.cfm?ID=1543

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STATIN-INDUCED CARDIOMYOPATHY

INTRODUCTION TO THE CITIZEN'S PETITION ON STATINS

By Peter H. Langsjoen, MD

The medical profession has, after more than 30 years of
excellent propaganda, successfully created the wholly
iatrogenic - "pseudo-disease" dubbed "hypercholesterolemia"
and the associated malady "cholesterol neurosis". After
decades of dismal failure to cure this "disease" of numbers
with low fat diets and a host of cholesterol lowering
drugs, the medical profession stumbled upon the magic
bullet, the cure for this dreaded artificial disease -
statins (HMG-CoA reductase inhibitors). First released on
the US market in 1987, statins have rapidly grown into one
of the most widely prescribed class of drugs in history.
Statins do three things:

1. They block the body's ability to make cholesterol, thus
lowering the blood level of cholesterol, thereby curing
cholesterol neurosis. Doctors and patients equally
neurotic have immediate gratification. The "evil" high
cholesterol has been dramatically lowered and the future
is bright and promising. So far...so good.

2. Unrelated to their cholesterol lowering, statins have
been found to have anti-inflammatory, plaque-
stabilizing properties which have a slight benefit in
coronary heart disease.

3. Statins kill people - lots of people - and they wound
many, many more. All patients taking statins become
depleted in Coenzyme Q10 (CoQ10), eventually - those
patients who start with a relatively low CoQ10 levels
(the elderly and patients with heart failure) begin to
manifest signs/symptoms of CoQ10 deficiency relatively
rapidly - in 6 to 12 months. Younger, healthier people
who's only "illness" is the non-illness
"hypercholesterolemia" can tolerate statins for several
years before getting into trouble with fatigue, muscle
weakness and soreness (usually with normal muscle enzyme
CPK tests) and most ominously - heart failure.

In my practice of 17 years in Tyler, Texas, I have seen a
frightening increase in heart failure secondary to statin
usage, "statin cardiomyopathy". Over the past five years,
statins have become more potent, are being prescribed in
higher doses, and are being used with reckless abandon in
the elderly and in patients with "normal" cholesterol
levels. We are in the midst of a CHF epidemic in the US with
a dramatic increase over the past decade. Are we causing
this epidemic through our zealous use of statins? In large
part I think the answer is yes. We are now in a position to
witness the unfolding of the greatest medical tragedy of all
time - never before in history has the medical establishment
knowingly (Merck & Co., Inc. has two 1990 patents combining
CoQ10 with statins to prevent CoQ10 depletion and attendant
side effects) created a life threatening nutrient deficiency
in millions of otherwise healthy people, only to then sit
back with arrogance and horrific irresponsibility and watch
to see what happens
- as I see two to three new statin cardiomyopathies per week
in my practice, I cannot help but view my once great
profession with a mixture of sorrow and contempt.

Statin-induced CoQ10 depletion is the topic of a recent
petition to the FDA requesting that this drug/nutrient
interaction be identified in a black box warning as part of
statin package insert information. A comprehensive review of
animal and human trials addressing this issue has been
submitted to the FDA as a supporting document. We, of
course, do not expect any response from the FDA, but 10
years from now when the full extent of statin toxicity
becomes painfully evident, at least we can, in good
conscience, know that we tried and who knows, sometimes
small sparks may spread in dry grass.

See Also:

Cholesterol Drugs And The Depletion Of Coenzyme Q10: A
Review Of Human And Animal Data. By Peter H. Langsjoen, MD

Citizen Petition: Needed - A Change In The Labeling Of All
Statin Drugs