I
Biomed Res. 2007 Apr;28(2):71-7.
Potentiation of intestinal immunity by micellary mushroom extracts.
Shen J, Ren H, Tomiyama-Miyaji C, Suga Y, Suga T, Kuwano Y, Iiai T,
Hatakeyama K, Abo T.
Department of Immunology, Niigata University School of Medicine.
Mushroom (shiitake) extracts were dispersed with lecithin micelles to
prepare superfine particles (0.05 to 0.2 mum in diameter) of beta-1,3-
glucan (micellary mushroom extracts). When mice were fed with these
micelles of beta-glucan (0.75 mg/day/mouse, smaller amounts of beta-
glucan), the number of lymphocytes yielded by the small intestine
increased by up to 40%. More interestingly, the ratio of
CD8alphabeta(+)TCRalphabeta(+) cells/CD8alphaalpha(+)TCRalphabeta(+)
cells increased prominently. In parallel with this deviation in the
distribution of lymphocyte subsets, tumor cytotoxicity against P815
cells and cytokine productions were also augmented. In other words,
phylogenetically developed lymphocytes (CD8alphabeta(+),
TCRalphabeta(+)) were much more effectively activated by the oral
administration of micellary beta-glucan. These results suggest that
smaller amounts of micellary beta-glucan might be useful for the
potentiation of intestinal immunity.
PMID: 17510491 [PubMed - in process]
Who loves ya.
Tom
Jesus Was A Vegetarian!
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DEAD PEOPLE WALKING
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Potentiation of intestinal immunity by micellary mushroom extracts.
Shen J, Ren H, Tomiyama-Miyaji C, Suga Y, Suga T, Kuwano Y, Iiai T,
Hatakeyama K, Abo T.
Department of Immunology, Niigata University School of Medicine.
Mushroom (shiitake) extracts were dispersed with lecithin micelles to
prepare superfine particles (0.05 to 0.2 mum in diameter) of beta-1,3-
glucan (micellary mushroom extracts). When mice were fed with these
micelles of beta-glucan (0.75 mg/day/mouse, smaller amounts of beta-
glucan), the number of lymphocytes yielded by the small intestine
increased by up to 40%. More interestingly, the ratio of
CD8alphabeta(+)TCRalphabeta(+) cells/CD8alphaalpha(+)TCRalphabeta(+)
cells increased prominently. In parallel with this deviation in the
distribution of lymphocyte subsets, tumor cytotoxicity against P815
cells and cytokine productions were also augmented. In other words,
phylogenetically developed lymphocytes (CD8alphabeta(+),
TCRalphabeta(+)) were much more effectively activated by the oral
administration of micellary beta-glucan. These results suggest that
smaller amounts of micellary beta-glucan might be useful for the
potentiation of intestinal immunity.
PMID: 17510491 [PubMed - in process]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk