D
Doe
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CONCLUSION: Both hyperinsulinemia induced by insulin resistance and iron overload represented by
ferritin elevation were significantly associated with NAFLD in obese patients.
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ijo/journal/vaop/ncurrent /abs/0802519a.html
http://tinyurl.com/wcjp
International Journal of Obesity advance online publication 11 November 2003;
doi:10.1038/sj.ijo.0802519
Paper Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in
apparently healthy obese patients
T-J Hsiao1, J-C Chen1 and J-D Wang2
1Department of Internal Medicine, Tao-Yuan General Hospital, Taiwan
2National Taiwan University Hospital, Department of Internal Medicine, Institute of Occupational
Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taiwan
Correspondence to: Dr J-D ****, Institute of Occupational Medicine and Industrial Hygiene, College
of Public Health, National Taiwan University, No. 1 Jen-Ai Rd Sec 1, Taipei 10018, Taiwan. E-mail:
[email protected]
Received 26 February 2003; revised 10 July 2003; accepted 5 September 2003; published online 11
November 2003
Abstract
OBJECTIVES: The aims of this study were to test the possible association between nonalcoholic fatty
liver disease (NAFLD) and iron and insulin resistance, and to determine the prevalence of NAFLD in
apparently healthy obese subjects.
DESIGN: Cross-sectional, clinical epidemiologic study.
SUBJECTS: A total of 210 apparently healthy obese patients, aged from 18 to 65 y, with a body mass
index (BMI) of 28 kg/m2 or more, were enrolled in a body weight reduction program in our hospital.
MEASUREMENTS: All the subjects underwent screening and preprogram examinations, including
anthropometric data measurements, biochemistry testing, and ultrasonography of the liver. NAFLD was
defined as fatty liver diagnosed by ultrasonograpgy plus persistent elevation of alanine
aminotransferase (ALT) levels.
RESULTS: Of the 210 patients, 80% (168/210) had fatty liver. Persistent ALT elevation in two
separate tests was further detected in 25.6% (43/168) of patients. Multiple logistic regression
analysis showed waist circumference and insulin resistance to be independently associated with fatty
liver. Serum ferritin level and insulin resistance were two major risk factors predicting NAFLD.
CONCLUSION: The prevalence of NAFLD was 20.5% (43/210) in obese patients. As both
hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin
elevation might damage hepatocytes, we concluded that these two factors were significantly
associated with NAFLD in obese patients.
Keywords
insulin resistance; ferritin; nonalcoholic fatty liver disease; waist circumference
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
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ferritin elevation were significantly associated with NAFLD in obese patients.
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ijo/journal/vaop/ncurrent /abs/0802519a.html
http://tinyurl.com/wcjp
International Journal of Obesity advance online publication 11 November 2003;
doi:10.1038/sj.ijo.0802519
Paper Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in
apparently healthy obese patients
T-J Hsiao1, J-C Chen1 and J-D Wang2
1Department of Internal Medicine, Tao-Yuan General Hospital, Taiwan
2National Taiwan University Hospital, Department of Internal Medicine, Institute of Occupational
Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taiwan
Correspondence to: Dr J-D ****, Institute of Occupational Medicine and Industrial Hygiene, College
of Public Health, National Taiwan University, No. 1 Jen-Ai Rd Sec 1, Taipei 10018, Taiwan. E-mail:
[email protected]
Received 26 February 2003; revised 10 July 2003; accepted 5 September 2003; published online 11
November 2003
Abstract
OBJECTIVES: The aims of this study were to test the possible association between nonalcoholic fatty
liver disease (NAFLD) and iron and insulin resistance, and to determine the prevalence of NAFLD in
apparently healthy obese subjects.
DESIGN: Cross-sectional, clinical epidemiologic study.
SUBJECTS: A total of 210 apparently healthy obese patients, aged from 18 to 65 y, with a body mass
index (BMI) of 28 kg/m2 or more, were enrolled in a body weight reduction program in our hospital.
MEASUREMENTS: All the subjects underwent screening and preprogram examinations, including
anthropometric data measurements, biochemistry testing, and ultrasonography of the liver. NAFLD was
defined as fatty liver diagnosed by ultrasonograpgy plus persistent elevation of alanine
aminotransferase (ALT) levels.
RESULTS: Of the 210 patients, 80% (168/210) had fatty liver. Persistent ALT elevation in two
separate tests was further detected in 25.6% (43/168) of patients. Multiple logistic regression
analysis showed waist circumference and insulin resistance to be independently associated with fatty
liver. Serum ferritin level and insulin resistance were two major risk factors predicting NAFLD.
CONCLUSION: The prevalence of NAFLD was 20.5% (43/210) in obese patients. As both
hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin
elevation might damage hepatocytes, we concluded that these two factors were significantly
associated with NAFLD in obese patients.
Keywords
insulin resistance; ferritin; nonalcoholic fatty liver disease; waist circumference
Who loves ya. Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking