I have a very old Trek Columbus road frame from about 1978. The big problem I ran into 10+ years ago was that I broke a Campy rear axle... And I was doomed. My bike was 126mm in the back end.
I took a big gamble and had the rear end spread out. Put on Veloce 8-speed with an Athena hub. I then gradually let it all evolve, and now run Record Ti hubs (the old kind that won't take an 11 because of the lock-ring's diameter) and Centaur. I put so many miles on the 2002 levers that I was forced to rebuild. You can't rebuild Shimano levers. I'm now to the point where I can remove a lever, take it apart, reassemble with new parts and put it back on the bike in 90 minutes -- without retaping. Not bad, eh?
Now I have a UT Centaur AL crank, and everything else is 2002 10-speed Centaur. It works great. I replaced the steel threaded fork with a Ritchey CF/AL fork, and the whole thing weighs just over 20. That's really not bad. But I do think my much newer LeMond handles better.
I'd put up a picture if it was clean. It's filthy right now. Needs a new chain. Yup, been riding it.
Been toying with the idea of a newer CF bike, so I rode a Fuji SL-1. I simply did not like the way it rode -- much too harsh for my old body. Plus, I just plain have better wheels (Record Ti/DT/Open Pro vs Aksiums on the Fuji). Plus, the Fuji is only 2 lbs lighter than what I have.
I will say that the LeMond is 100% 105, except for the Ultegra 3 by 10 levers. I like Shimano too. Ultegra is awfully sweet. You'll find great Ultegra deals at Total/Nashbar/Wiggle/et al. I saw the gruppo for under $1k recently. Hard to resist at that price.
I went Centaur Compact (50-34, 12-25) and 105 Triple (50-39-30, 12-25); I call them my "concession speech bikes", even if I can still ride 70 miles in 3-1/2 hours.
The good news here is you can't go wrong.