Endothelial Dysfunction and Increased Arterial Intima-Media Thickness in Children With Type 1 Diabet



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BACKGROUND: Endothelial dysfunction may play a
pathophysiological role in the development of
atherosclerosis in subjects with type 1 diabetes. We
examined whether alterations in vascular endothelial
function exist in children with type 1 diabetes and tested
the hypothesis that endothelial dysfunction is associated
with early structural atherosclerotic vascular changes in
these children.

CONCLUSIONS: Impaired FMD response is a common manifestation
in children with type 1 diabetes and is associated with
increased carotid artery IMT. These data suggest that
endothelial dysfunction in children with type 1 diabetes may
predispose them to the development of early atherosclerosis.

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