Accelerated oxidative stress / multiple sclerosis

Doe

Mult Scler. 2004 Jun;10(3):266-71. Related Articles, Links

Association of apolipoprotein E and myeloperoxidase
genotypes to clinical course of familial and sporadic
multiple sclerosis.

Zakrzewska-Pniewska B, Styczynska M, Podlecka A, Samocka R,
Peplonska B, Barcikowska M, Kwiecinski H.

Department of Neurology, The Medical University of Warsaw,
02-097 Warsaw, Banacha 1A, Str., Poland. beza@amwaw.edu.pl

The importance of apolipoprotein E (ApoE) and
myeloperoxidase (MPO) genotypes in the clinical
characteristics of multiple sclerosis (MS) has been recently
emphasized. In a large group of Polish patients we have
tested the hypothesis that polymorphism in ApoE and MPO
genes may influence the course of the disease. Genotypes
were determined in 117 MS patients (74 females and 43 males;
99 sporadic and 18 familial cases) with mean EDSS of 3.6,
mean age of 44. 1 years, mean duration of the disease 12.8
years and mean onset of MS at 31.2 years, and in 100 healthy
controls. The relationship between ApoE and MPO genes'
polymorphism and the MS activity as well as the defect of
remyelination (diffuse demyelination) and brain atrophy on
MRI were analysed. The ApoE epsilon4 allele was not related
to the disease course or the ApoE epsilon2 to the intensity
of demyelination on MRI. The genotype MPO G/G was found in
all familial MS and in 57% (56/99) of sporadic cases. This
genotype was also related to more pronounced brain atrophy
on MRI. The MPO G/G subpopulation was characterized by a
significantly higher proportion of patients with secondary
progressive MS (P < 0.05) and by a higher value of EDSS.
According to our results the MPO G allele is frequently
found (in 96% of cases) among Polish patients with MS. More
severe nervous tissue damage in the MPO G/G form can be
explained by the mechanism of accelerated oxidative stress.
It seems that MPO
G/G genotype may be one of the genetic factors influencing
the progression rate of disability in MS patients.

PMID: 15222689 [PubMed - in process]

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