Lecithin and Ureteral Obstruction Therapy

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Lecithin .. again .. ?
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Medical News Article on Ureteral Obstruction Therapy

Reports on ureteral obstruction therapy findings from Inonu
University, Department of Pediatric Surgery provide new insights

2007 JUN 18 -- Investigators publish new data in the report
"Attenuation of ureteral obstruction-induced renal injury by
polyenylphosphatidylcholine." According to recent research from
Malatya, Turkey, "The cytoprotective, antioxidant and antifibrotic
effects of polyenylphosphatidylcholine (lecithin, PPC) have been
demonstrated both experimentally and clinically. The present study
investigated whether PPC treatment has any beneficial effect on renal
injury in unilateral partial ureteral obstruction (UUO) in rats."
"Forty Wistar-Albino rats were split into three groups (sham-
operated controls, untreated and treated rats). Rats of the untreated
and treated groups...


http://www.ingentaconnect.com/conte...000004/art00018

Attenuation of ureteral obstruction-induced renal injury by
polyenylphosphatidylcholine
Authors: Akin, Melih1; Demirbilek, Savas; AY, Selma2; Gurunluoglu,
Kubilay1; Turkmen, Emine3; Tas, Erkan1; Aksoy, Rauf Tugrul1;
Baykarabulut, Aysun4; Edali, Mehmet Naci3

Source: International Journal of Urology, Volume 14, Number 4, April
2007 , pp. 350-356(7)

Abstract:

Background:

The cytoprotective, antioxidant and antifibrotic effects of
polyenylphosphatidylcholine (lecithin, PPC) have been demonstrated
both experimentally and clinically. The present study investigated
whether PPC treatment has any beneficial effect on renal injury in
unilateral partial ureteral obstruction (UUO) in rats. Methods:

Forty Wistar-Albino rats were split into three groups (sham-operated
controls, untreated and treated rats). Rats of the untreated and
treated groups (n = 15) underwent UUO with two-thirds of the left
ureter embedded in the psoas muscle. In group 3, PPC was given orally
at a dose of 100 mg/day for 30 days. At the end of the 30thday of the
experimental period, obstructed kidneys and blood samples were
harvested. To investigate the therapeutic efficacy of PPC treatment in
UUO kidneys, oxidant and antioxidant enzyme levels, lipid
peroxidation, proinflammatory cytokines (interleukin-1, interleukin-6,
tumor necrosis factor alpha), transforming growth factor beta-1
(TGFβ-1), alpha smooth muscle actin (α-SMA) and nuclear factor kappa
beta (NF-κβ) expression, leukocyte infiltration (ED1, ED2, CD4 and CD8
immunohistochemistry), and tubulointerstitial damage in the obstructed
kidneys were studied. Results:

Oxidative stress, neutrophil infiltration, release of cytotoxic
mediators, TGFβ-1 levels, tubulointerstitial damage, alpha-SMA and NF-
KB expressions in kidney tissue were significantly increased in the
UUO rats. PPC treatment attenuated oxidative stress, leukocyte
infiltration, cytotoxic mediator, and TGFβ-1 levels and also decreased
expressions of α-SMA and NF-κβ. It was associated with decreased
tubulointerstitial damage, compared with UUO alone. Conclusions:

These results indicate that PPC treatment protects against UUO-induced
renal injury in rats possibly through its antioxidant, anti-
inflammatory and antifibrotic actions.
Keywords: alpha smooth muscle actin; nuclear factor kappa beta;
polyenylphosphatidylcholine; transforming growth factor-beta1;
unilateral ureteral obstruction

Document Type: Research article

DOI: 10.1111/j.1442-2042.2006.01717.x

Affiliations: 1: Departments of Pediatric Surgery, 2: Microbiology, 3:
Pathology, and 4: Biochemistry, School of Medicine, Inonu University,
Malatya, Turkey


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