asthma / iron / acidosis

Doe

What relationship could? .. ph / acidosis have on the
frequency / severity of asthma attacks?

It has been shown and extensively used .. ph .. in the
Intensive Care Unit .. in those with acute asthma attacks
are 'treated' with injection of bicarbonate of soda.

This is a 'base' / alkaline which in theory would raise the
ph of the body 'back into' a state of .. normal.

Would / could this ph change BE .. related .. to the fact
of elevated iron levels recently shown to BE in children
with asthma?

http://tinyurl.com/yuwc7

And HOW is this related to this study ?

This study shows anaphylactic shock is related somehow TO
the 'saturation' OF the iron complexes.

http://tinyurl.com/2blnp

So in those WITH iron excess .. as in the study below ..
acidic conditions NOW allow for the 'spillage' of iron ..
would / could the SAME occur in those with asthma?

<<snip>> acidosis temporarily disrupts the capacity of
transferrin to bind iron <<snip>>

Diabetes. 1982 Dec;31(12):1109-14. Related Articles, Links

A mechanism of susceptibility to mucormycosis in diabetic
ketoacidosis: transferrin and iron availability.

Artis WM, Fountain JA, Delcher HK, Jones HE.

The defect in host defense that makes the diabetic
ketoacidotic (DKA) patient susceptible to mucormycosis has
not been identified. Sera from 10 DKA patients and three
normal volunteers were tested for their capacity to support
the in vitro growth of a common etiologic agent of
mucormycosis, Rhizopus oryzae. After equilibration with room
air none of the normal or DKA sera, each of which was now
extremely alkaline, supported growth of R. oryzae. When the
sera were placed in a CO2 atmosphere that permitted
simulation of the in vivo clinical pH (normal 7.40 and DKA
7.3-6.6), four of seven DKA sera supported profuse fungal
growth. No growth occurred in normal serum. The three DKA
sera that did not support fungal growth at pH less than or
equal to 7.3 contained less iron (x = 13 micrograms/dl) than
the four sera that supported profuse fungal growth (x = 69
micrograms/dl). Increasing the iron content of iron-poor DKA
serum that did not support R. oryzae growth allowed profuse
growth at acidotic conditions but not at pH greater than or
equal to 7.4. Simulated acidotic conditions (pH
7.3-6.6) also decreased the iron-binding capacity of normal
serum stepwise from 266 micrograms/dl to 0. Our data
indicate that acidosis temporarily disrupts the capacity
of transferrin to bind iron and suggest that this
alteration abolishes an important host defense mechanism
that permits growth of R. oryzae.

PMID: 6816646 [PubMed - indexed for MEDLINE]

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