Circulating Oxidized Low-Density Lipoprotein and Its Association With Carotid Intima-Media Thickness



S

Sonos

Guest
~~ Nothing suprising about this study, but I found it
interesting that oxidized LDL is independently associated
with increased carotid intima media thickness.~~Sonos

Arterioscler Thromb Vasc Biol. 2004 Jun 17 [Epub ahead of
print]

Circulating Oxidized Low-Density Lipoprotein and Its
Association With Carotid Intima-Media Thickness in
Asymptomatic Members of Familial Combined
Hyperlipidemia Families.

Liu ML, Ylitalo K, Salonen R, Salonen JT, Taskinen MR.

Department of Medicine, Helsinki University Central
Hospital, University of Helsinki, Finland; Research
Institute of Public Health, University of Kuopio, Finland;
and Inner Savo Health Centre, Suonenjoki, Finland.

OBJECTIVE: Oxidized low-density lipoprotein (Ox-LDL)is
implicated in the pathogenesis of atherosclerosis.
Circulating oxidation-specific epitopes on plasma Ox-LDL
has been linked with coronary artery disease, but its
determinants and its association with early development of
atherosclerosis in familial combined hyperlipidemia (FCHL)
has not been very well studied. This study aimed to
investigate the determinants of the circulating Ox-LDL and
the association between Ox-LDL and carotid intima-media
thickness (IMT) in asymptomatic members of FCHL families.
METHODS AND RESULTS: Ox-LDL, susceptibility of LDL to
oxidation in vitro, plasma 8-isoprostane and antioxidants,
lipids and lipoproteins, LDL particle size, and carotid IMT
were measured in 150 asymptomatic FCHL family members.
Affected FCHL family members had reduced LDL particle size
and lag time for LDL oxidation, increased plasma levels of
Ox-LDL, increased plasma urate and alpha-tocopherol, and a
trend for the increase of 8-isoprostane as compared with
nonaffected FCHL. Ox-LDL was independently associated with
serum LDL cholesterol, apoB, and 8-isoprostane in
multivariate analysis but only univariately correlated with
LDL particle size and lag time for LDL oxidation. In
addition, Ox-LDL was significantly associated with carotid
mean IMT independently of other clinical and biochemical
variables in a multivariate model. CONCLUSIONS: Serum LDL
cholesterol, apoB levels, and 8-isoprostane were the most
important determinants of Ox-LDL. Ox-LDL is independently
associated with carotid IMT in asymptomatic FCHL family
members and can be used as a marker of early
atherosclerosis in FCHL.

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