Circulating Oxidized Low-Density Lipoprotein and Its Association With Carotid Intima-Media Thickness

Discussion in 'Health and medical' started by Sonos, Jun 19, 2004.

  1. Sonos

    Sonos Guest

    ~~ Nothing suprising about this study, but I found it
    interesting that oxidized LDL is independently associated
    with increased carotid intima media thickness.~~Sonos

    Arterioscler Thromb Vasc Biol. 2004 Jun 17 [Epub ahead of
    print]

    Circulating Oxidized Low-Density Lipoprotein and Its
    Association With Carotid Intima-Media Thickness in
    Asymptomatic Members of Familial Combined
    Hyperlipidemia Families.

    Liu ML, Ylitalo K, Salonen R, Salonen JT, Taskinen MR.

    Department of Medicine, Helsinki University Central
    Hospital, University of Helsinki, Finland; Research
    Institute of Public Health, University of Kuopio, Finland;
    and Inner Savo Health Centre, Suonenjoki, Finland.

    OBJECTIVE: Oxidized low-density lipoprotein (Ox-LDL)is
    implicated in the pathogenesis of atherosclerosis.
    Circulating oxidation-specific epitopes on plasma Ox-LDL
    has been linked with coronary artery disease, but its
    determinants and its association with early development of
    atherosclerosis in familial combined hyperlipidemia (FCHL)
    has not been very well studied. This study aimed to
    investigate the determinants of the circulating Ox-LDL and
    the association between Ox-LDL and carotid intima-media
    thickness (IMT) in asymptomatic members of FCHL families.
    METHODS AND RESULTS: Ox-LDL, susceptibility of LDL to
    oxidation in vitro, plasma 8-isoprostane and antioxidants,
    lipids and lipoproteins, LDL particle size, and carotid IMT
    were measured in 150 asymptomatic FCHL family members.
    Affected FCHL family members had reduced LDL particle size
    and lag time for LDL oxidation, increased plasma levels of
    Ox-LDL, increased plasma urate and alpha-tocopherol, and a
    trend for the increase of 8-isoprostane as compared with
    nonaffected FCHL. Ox-LDL was independently associated with
    serum LDL cholesterol, apoB, and 8-isoprostane in
    multivariate analysis but only univariately correlated with
    LDL particle size and lag time for LDL oxidation. In
    addition, Ox-LDL was significantly associated with carotid
    mean IMT independently of other clinical and biochemical
    variables in a multivariate model. CONCLUSIONS: Serum LDL
    cholesterol, apoB levels, and 8-isoprostane were the most
    important determinants of Ox-LDL. Ox-LDL is independently
    associated with carotid IMT in asymptomatic FCHL family
    members and can be used as a marker of early
    atherosclerosis in FCHL.

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