Obesity / iron / NAFLD

Discussion in 'Health and medical' started by Doe, Jan 12, 2004.

  1. Doe

    Doe Guest

    CONCLUSION: Both hyperinsulinemia induced by insulin resistance and iron overload represented by
    ferritin elevation were significantly associated with NAFLD in obese patients.

    http://www.nature.com/cgi-taf/DynaPage.taf?file=/ijo/journal/vaop/ncurrent /abs/0802519a.html

    http://tinyurl.com/wcjp

    International Journal of Obesity advance online publication 11 November 2003;
    doi:10.1038/sj.ijo.0802519

    Paper Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in
    apparently healthy obese patients

    T-J Hsiao1, J-C Chen1 and J-D Wang2

    1Department of Internal Medicine, Tao-Yuan General Hospital, Taiwan

    2National Taiwan University Hospital, Department of Internal Medicine, Institute of Occupational
    Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taiwan

    Correspondence to: Dr J-D Wang, Institute of Occupational Medicine and Industrial Hygiene, College
    of Public Health, National Taiwan University, No. 1 Jen-Ai Rd Sec 1, Taipei 10018, Taiwan. E-mail:
    jdwang@ha.mc.ntu.edu.tw

    Received 26 February 2003; revised 10 July 2003; accepted 5 September 2003; published online 11
    November 2003

    Abstract

    OBJECTIVES: The aims of this study were to test the possible association between nonalcoholic fatty
    liver disease (NAFLD) and iron and insulin resistance, and to determine the prevalence of NAFLD in
    apparently healthy obese subjects.

    DESIGN: Cross-sectional, clinical epidemiologic study.

    SUBJECTS: A total of 210 apparently healthy obese patients, aged from 18 to 65 y, with a body mass
    index (BMI) of 28 kg/m2 or more, were enrolled in a body weight reduction program in our hospital.

    MEASUREMENTS: All the subjects underwent screening and preprogram examinations, including
    anthropometric data measurements, biochemistry testing, and ultrasonography of the liver. NAFLD was
    defined as fatty liver diagnosed by ultrasonograpgy plus persistent elevation of alanine
    aminotransferase (ALT) levels.

    RESULTS: Of the 210 patients, 80% (168/210) had fatty liver. Persistent ALT elevation in two
    separate tests was further detected in 25.6% (43/168) of patients. Multiple logistic regression
    analysis showed waist circumference and insulin resistance to be independently associated with fatty
    liver. Serum ferritin level and insulin resistance were two major risk factors predicting NAFLD.

    CONCLUSION: The prevalence of NAFLD was 20.5% (43/210) in obese patients. As both
    hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin
    elevation might damage hepatocytes, we concluded that these two factors were significantly
    associated with NAFLD in obese patients.

    Keywords

    insulin resistance; ferritin; nonalcoholic fatty liver disease; waist circumference

    Who loves ya. Tom


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