On May 15, 9:10 pm, traveler <Vallec...@aol.com> wrote: > Heavy multivitamin use may be linked to advanced prostate cancer. > While regular multivitamin use is not linked with early or localized > prostate cancer, taking too many multivitamins may be associated with > an increased risk for advanced or fatal prostate cancers, according to > a study in the May 16 issue of the Journal of the National Cancer > Institute. > > Millions of Americans take multivitamins because of a belief in their > potential health benefits, even though there is limited scientific > evidence that they prevent chronic disease. Researchers have wondered > what impact multivitamin use might have on cancer risk. > > Karla Lawson, Ph.D., of the National Cancer Institute in Bethesda, > Md., and colleagues followed 295,344 men enrolled in the National > Institutes of Health-AARP Diet and Health Study to determine the > association between multivitamin use and prostate cancer risk. After > five years of follow-up, 10,241 men were diagnosed with prostate > cancer, including 8,765 with localized cancers and 1,476 with advanced > cancers. > > The researchers found no association between multivitamin use and the > risk of localized prostate cancer. But they did find an increased risk > of advanced and fatal prostate cancer among men who used multivitamins > more than seven times a week, compared with men who did not use > multivitamins. The association was strongest in men with a family > history of prostate cancer and men who also took selenium, beta- > carotene, or zinc supplements. > > "Because multivitamin supplements consist of a combination of several > vitamins and men using high levels of multivitamins were also more > likely to take a variety of individual supplements, we were unable to > identify or quantify individual components responsible for the > associations that we observed," the authors write. > > In an accompanying editorial, Goran Bjelakovic, M.D., of the > University of Nis in Serbia, and Christian Gluud, M.D., of Copenhagen > University Hospital in Denmark, discuss the positive and negative > health effects of antioxidant supplements. "Lawson [and colleagues] > add to the growing evidence that questions the beneficial value of > antioxidant vitamin pills in generally well-nourished populations and > underscore the possibility that antioxidant supplements could have > unintended consequences for our health," the authors write. > > Contact: > > · Article: National Cancer Institute Media Relations Branch, > 301-496-6641, ncipressoffic...@mail.nih.gov > > · Editorial: > > o Goran Bjelakovic, gor...@junis.ni.ac.yu > > o Christian Gluud, cgl...@ctu.rh.dk > > Citations: > > · Article: Lawson KA, Wright ME, Subar A, Mouw T, Schatzkin A, > Leitzmann MF. Multivitamin Use and Risk of Prostate Cancer in the > National Institutes of Health - AARP Diet and Health Study. J Natl > Cancer Inst 2007; 99: 754-764 > > · Editorial: Bjelakovic G, Gluud C. Surviving Antioxidant Supplements. > J Natl Cancer Inst 2007; 99: 742-743 > > Note: The Journal of the National Cancer Institute is published by > Oxford University Press and is not affiliated with the National Cancer > Institute. Attribution to the Journal of the National Cancer Institute > is requested in all news coverage. Visit the Journal online athttp://jnci..oxfordjournals.org/.