J
John De Hoog
Guest
Alf Christophersen wrote...
> One problem with betaine is that it is quite osmotic active and activated aldose reductase which
> produce sorbitol from glucose in cells, which is also osmotic active and are very little mobile
> over membranes since it is sterically hindered to pass the Cl-regulated channel that do release
> taurine and beta-alanine when cell is volume or osmotically challenged (hypoosmosis), the
> increased sorbitol steady-state concentration if rate of turnover is not increased in parallell
> with synthesis will increase osmotic pressure inside and thus force taurine and betaine to leave
> cell thus making lack of protection against hyperhomocysteinamia and lack of protection against
> uncontrolled glycation, eg. by lysine of fructose to form an Amadori product 1-amino-1-
> deoxyfructose lysine adduct) which most possibly taurine may prevent to be formed by substituting
> lysine in the normal reaction since normally, taurine will be in great excess as free amino acid
> in cells (maybe one of the reasons intake of free amino acids may be hazardous, while intake of
> taurine is not dangerous at all since that will increase protection against formation of such
> derangeous products as AGEs.
Alf,
That was a bit difficult to follow, but what happens to people (like us) who supplement 2 grams of
taurine a day in addition to a moderate amount of betaine?
--
John de Hoog http://dehoog.org
> One problem with betaine is that it is quite osmotic active and activated aldose reductase which
> produce sorbitol from glucose in cells, which is also osmotic active and are very little mobile
> over membranes since it is sterically hindered to pass the Cl-regulated channel that do release
> taurine and beta-alanine when cell is volume or osmotically challenged (hypoosmosis), the
> increased sorbitol steady-state concentration if rate of turnover is not increased in parallell
> with synthesis will increase osmotic pressure inside and thus force taurine and betaine to leave
> cell thus making lack of protection against hyperhomocysteinamia and lack of protection against
> uncontrolled glycation, eg. by lysine of fructose to form an Amadori product 1-amino-1-
> deoxyfructose lysine adduct) which most possibly taurine may prevent to be formed by substituting
> lysine in the normal reaction since normally, taurine will be in great excess as free amino acid
> in cells (maybe one of the reasons intake of free amino acids may be hazardous, while intake of
> taurine is not dangerous at all since that will increase protection against formation of such
> derangeous products as AGEs.
Alf,
That was a bit difficult to follow, but what happens to people (like us) who supplement 2 grams of
taurine a day in addition to a moderate amount of betaine?
--
John de Hoog http://dehoog.org