Antibiotics and Increased Breast Cancer: Low DHEA


James Michael H

"Antibiotic Use in Relation to the Risk
of Breast Cancer," C.M. Velicer, et al., Journal of the American Medical
Association 2004; 291: 827-835

Velicer, et al., reported that the "Use of antibiotics is associated with increased risk of incident
and fatal breast cancer."

Copyright 2004, James Michael Howard, Fayetteville, Arkansas, U.S.A.

It is my hypothesis (1994) that low dehydroepiandrosterone (DHEA) may trigger oncogenes and that
high testosterone may reduce DHEA, therefore increasing the probability of cancer. Both of these
have since received support. For example, hormone replacement therapy decreases DHEA and HRT has
been found to increase the incidence of breast cancer. Also, consumption of ethanol by women
increases testosterone; alcohol consumption by women has been connected with increased breast
cancer. ("How 'Hormone Replacement Therapy' (HRT) May Cause Breast Cancer" at .)

It is known that DHEA exerts protective effects against many forms of infections, including
bacteria. I suggest the connection of increased breast cancer in women who have required antibiotics
is low DHEA. That is, low DHEA in these women reduced their immune response which subsequently
required the aid of antibiotics. I suggest the increased incidence of breast cancer in these women
is reduced DHEA, not antibiotics.

James Michael Howard