Antioxidants and Pregnancy / Preeclampsia



D

Doe

Guest
Gynecol Obstet Invest. 2004;58(1):8-13. Epub 2004 Feb 25. Related Articles, Links

Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme
Q(10), alpha-Tocopherol and gamma-Tocopherol in Preeclampsia and Normal Pregnancy.

Palan PR, Shaban DW, Martino T, Mikhail MS.

Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center/Albert Einstein College of
Medicine, Bronx, N.Y., USA.

It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate
increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this
study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q(10), alpha-
tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three
antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe
preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was
observed in serum levels of coenzyme Q(10) and alpha-tocopherol (p < 0.001 for each by the Kruskal-
Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-
Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed
significant association between grades of preeclampsia and both serum coenzyme Q(10) and alpha-
tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q(10) and alpha-tocopherol are
potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter
the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against
free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.
Copyright 2004
R. Karger AG, Basel

PMID: 14988604 [PubMed - as supplied by publisher]

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M

markd

Guest
And what exactly are we to make of this, how does it relate to any body of theory, to what practical
use is it, and to what goal can it be useful? Without this information it is but another random
abstract plucked from the web, one among thousands of such.
 
D

Doe

Guest
>Subject: Re: Antioxidants and Pregnancy / Preeclampsia
>From: [email protected]
>Date: 3/3/2004 8:59 AM Mountain Standard Time
>Message-id: <[email protected]>
>
>And what exactly are we to make of this,

Me .. ? I believe it speaks to .. preclampsia a problem which many times deals with death of
the child.

> how does it relate to any body of theory,

I believe it relates to a healthy level of antioxidants in the body are associated with a healthier
outcome at birth.

>to what practical use is it,

Keeping women from having stillbirths .. deformed babies and spontaneous abortions ..

>and to what goal can it be useful?

Fewer deaths ..

>Without this information it is but another random abstract plucked from the web, one among
>thousands of such.

Without the ABILITY to actually be able to understand even the simplest medical study .. such as the
one below .. I believe maybe you should find another line of work.. IF this IS your line of work.

Gynecol Obstet Invest. 2004;58(1):8-13. Epub 2004 Feb 25. Related Articles, Links

Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme
Q(10), alpha-Tocopherol and gamma-Tocopherol in Preeclampsia and Normal Pregnancy.

Palan PR, Shaban DW, Martino T, Mikhail MS.

Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center/Albert Einstein College of
Medicine, Bronx, N.Y., USA.

It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate
increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this
study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q(10), alpha-
tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three
antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe
preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was
observed in serum levels of coenzyme Q(10) and alpha-tocopherol (p < 0.001 for each by the Kruskal-
Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-
Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed
significant association between grades of preeclampsia and both serum coenzyme Q(10) and alpha-
tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q(10) and alpha-tocopherol are
potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter
the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against
free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.
Copyright 2004
R. Karger AG, Basel

PMID: 14988604 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
M

markd

Guest
Thank you, finally, for providing some motivation for posting abstracts in a seemingly random
manner. While preggie women among the readers might find it useful to consider, they are left with
no practical application of the information. We are still at a loss as to what body of theory it
applies and why it should be read and considered in light of it. You have provided what is
basically a restatment of the abstract with a bit of expansion. One might add that it is critiful
for preggie and nursing mothers to often get additional nutrients because of the greater rate at
which they are depleted from the mother's body, this is an ironclad rule for both mother and docter
to keep fully in mind.

>>And what exactly are we to make of this,
>
>Me .. ? I believe it speaks to .. preclampsia a problem which many times deals with death of the
> child.
>
>> how does it relate to any body of theory,
>
>I believe it relates to a healthy level of antioxidants in the body are associated with a healthier
>outcome at birth.
>
>>to what practical use is it,
>
>Keeping women from having stillbirths .. deformed babies and spontaneous abortions ..
>
>>and to what goal can it be useful?
>
>Fewer deaths ..
>
>>Without this information it is but another random abstract plucked from the web, one among
>>thousands of such.
>
>Without the ABILITY to actually be able to understand even the simplest medical study .. such
>as the one below .. I believe maybe you should find another line of work.. IF this IS your
>line of work.
>
>Gynecol Obstet Invest. 2004;58(1):8-13. Epub 2004 Feb 25. Related Articles, Links
>
>
>Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme
>Q(10), alpha-Tocopherol and gamma-Tocopherol in Preeclampsia and Normal Pregnancy.
>
>Palan PR, Shaban DW, Martino T, Mikhail MS.
>
>Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center/Albert Einstein College of
>Medicine, Bronx, N.Y., USA.
>
>It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate
>increased attacks of free radicals, which may result in endothelial cell damage. The purpose of
>this study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q(10),
>alpha-tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all
>three antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with
>severe preeclampsia were measured by high-pressure liquid chromatography. A significant decrease
>was observed in serum levels of coenzyme Q(10) and alpha-tocopherol (p < 0.001 for each by the Kruskal-
>Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-
>Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed
>significant association between grades of preeclampsia and both serum coenzyme Q(10) and alpha-
>tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q(10) and alpha-tocopherol are
>potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter
>the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against
>free radical damage. This could be a factor in the endothelial cell damage observed in
>preeclampsia. Copyright 2004
>S. Karger AG, Basel
>
>PMID: 14988604 [PubMed - as supplied by publisher]
>
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>------
>
>Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
>http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
>http://pages.ivillage.com/ironjustice/deadpeoplewalking