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Gynecol Obstet Invest. 2004;58(1):8-13. Epub 2004 Feb 25. Related Articles, Links
Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme
Q(10), alpha-Tocopherol and gamma-Tocopherol in Preeclampsia and Normal Pregnancy.
Palan PR, Shaban DW, Martino T, Mikhail MS.
Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center/Albert Einstein College of
Medicine, Bronx, N.Y., USA.
It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate
increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this
study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q(10), alpha-
tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three
antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe
preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was
observed in serum levels of coenzyme Q(10) and alpha-tocopherol (p < 0.001 for each by the Kruskal-
Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-
Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed
significant association between grades of preeclampsia and both serum coenzyme Q(10) and alpha-
tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q(10) and alpha-tocopherol are
potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter
the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against
free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.
Copyright 2004
R. Karger AG, Basel
PMID: 14988604 [PubMed - as supplied by publisher]
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http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
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Lipid-Soluble Antioxidants and Pregnancy: Maternal Serum Levels of Coenzyme
Q(10), alpha-Tocopherol and gamma-Tocopherol in Preeclampsia and Normal Pregnancy.
Palan PR, Shaban DW, Martino T, Mikhail MS.
Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center/Albert Einstein College of
Medicine, Bronx, N.Y., USA.
It has been hypothesized that in preeclampsia, the antioxidant-deficient state may facilitate
increased attacks of free radicals, which may result in endothelial cell damage. The purpose of this
study was to investigate the association of three lipid-soluble antioxidants, coenzyme Q(10), alpha-
tocopherol and gamma-tocopherol, with preeclampsia and normal pregnancy. Serum levels of all three
antioxidants in 42 women with normal pregnancies, 25 with mild preeclampsia and 28 with severe
preeclampsia were measured by high-pressure liquid chromatography. A significant decrease was
observed in serum levels of coenzyme Q(10) and alpha-tocopherol (p < 0.001 for each by the Kruskal-
Wallis rank test) in women with preeclampsia compared to levels in normal pregnancy. gamma-
Tocopherol levels were comparable among the different groups. Logistic regression analysis revealed
significant association between grades of preeclampsia and both serum coenzyme Q(10) and alpha-
tocopherol levels (p = 0.000 and 0.030, respectively). Coenzyme Q(10) and alpha-tocopherol are
potent antioxidants, and the decreased levels of these two antioxidants in preeclampsia may alter
the normal redox balance, thereby reducing the ability of antioxidant defenses to protect against
free radical damage. This could be a factor in the endothelial cell damage observed in preeclampsia.
Copyright 2004
R. Karger AG, Basel
PMID: 14988604 [PubMed - as supplied by publisher]
--------------------------------------------------------------------------
------
Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking