Antioxidants / demyelinating diseases

Discussion in 'Health and medical' started by Doe, Dec 25, 2003.

  1. Doe

    Doe Guest

    Arch Biochem Biophys. 2004 Jan 1;421(1):54-60. Related Articles, Links

    Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells.

    Ernst A, Stolzing A, Sandig G, Grune T.

    Neuroscience Research Center, Medical Faculty (Charite), Humboldt University, Berlin, Germany

    Oxidative stress is supposed to play an important role in demyelinating diseases. Oligodendrocytes
    are the myelin-forming cells in the brain and are highly susceptible to oxidative stress due to
    their low antioxidative defense systems and high metabolic rate. In the present work, we tested the
    response of the oligodendrocyte cell line OLN 93 to oxidative stress. OLN 93 cell cultures are
    characterized by a loss of cell viability after oxidation. This loss of cell viability is
    accompanied by an increase in protein oxidation and consequently an elevated overall proteolysis. To
    minimize the oxidative damage, we tested the effects of the antioxidants alpha-lipoic acid and
    coenzyme Q(10). Both compounds were able to elevate cell viability and to decrease intracellular
    protein turnover and oxidant induced protein oxidation. Therefore, we concluded that the excessive
    oxidative damage of oligodendrocytes and their protein pool can be prevented by the usage of

    PMID: 14678784 [PubMed - in process]


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