Antioxidants / treatment of Graves' disease

Discussion in 'Health and medical' started by Doe, Feb 19, 2004.

  1. Doe

    Doe Guest

    <<snip>> Conclusion: The results of the study clearly indicate that supplementation with
    antioxidants in the treatment of Graves' disease is justified, particularly those containing
    selenium <<snip>>

    1: Clin Chim Acta. 2004 Mar;341(1-2):55-63. Related Articles, Links

    Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione
    peroxidase activity and concentration of selenium.

    Vrca VB, Skreb F, Cepelak I, Romic Z, Mayer L.

    Department of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of
    Zagreb, Croatia.

    Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and
    E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of
    patients with Graves' disease, treated with methimazole. Methods: The activity of glutathione
    peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in
    serum were measured, prior to commencement of therapy and after 30 and 60 days. Results: Patients
    who received supplementation with antioxidants in addition to therapy with methimazole (Group A,
    n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B, n=28).
    The concentration of selenium in the serum of patients in Group A increased significantly during
    treatment (p<0.001), while there was no statistically significant change in the patients in Group B.
    The concentration of selenium in the serum between the groups differed statistically significantly
    30 days (p<0.05) and 60 days (p<0.01) after the commencement of therapy. Activity of glutathione
    peroxidase in whole blood increased during treatment in both groups of patients. However, a
    statistically more significant increase occurred in Group A compared to Group B, 30 days after the
    commencement of therapy (p<0.01). Conclusion: The results of the study clearly indicate that
    supplementation with antioxidants in the treatment of Graves' disease is justified, particularly
    those containing selenium.

    PMID: 14967159 [PubMed - in process]

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