Apotransferrin / stimulating remyelination

Discussion in 'Health and medical' started by Doe, Feb 26, 2004.

  1. Doe

    Doe Guest

    Neurochem Res. 2003 Jan;28(1):101-10. Related Articles, Links

    Morphological changes of myelin sheaths in rats intracranially injected with apotransferrin.

    Marta CB, Paez P, Lopez M, Pellegrino de Iraldi A, Soto EF, Pasquini JM.

    Departamento de Quimica Biologica and Instituto de Quimica y Fisicoquimica Biologicas (IQUIFIB), UBA-
    CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina.

    Previous findings from our laboratories indicate that the intracranial injection of apotransferrin
    (aTf) in neonatal rats produces an accelerated oligodendrocyte maturation and an enhanced production
    and deposition of myelin membranes in the brain. To evaluate the anatomical distribution and the
    morphological characteristics of the myelin in these rats, we analyzed the optic nerves, cerebellum,
    and selected areas of brain sections from aTf-treated and control rats by both light and electron
    microscopy. Microscopic identification of myelin using a specific staining procedure, showed that in
    aTf-injected rats, in coincidence with previous biochemical studies, there was an increased
    deposition of myelin in selected areas of the nervous system. Qualitative and quantitative analysis
    of electron micrographs from areas showing increased myelinaton, such as the optic nerves and the
    corpus callosum, showed that among other changes, the intracranial treatment with aTf produces
    ultrastructural evidences of myelin decompaction, consisting of an enlargement in the distance
    between adjacent major dense lines, a decreased density of the intraperiod line, and an increased
    electron density of the major dense line, accompanied by a significant increase in its width. The
    intracranial administration of aTf induces an increased deposition of myelin by oligodeudroglial
    cells (OLGc), and these myelin membranes, in spite of the changes in composition and in morphology,
    appear to function normally. Apotransferrin can be considered as a differentiation factor that could
    be used to stimulate remyelination in cases in which myelin has been destroyed by various
    pathological processes.

    PMID: 12587668 [PubMed - indexed for MEDLINE]

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