Apple juice / cognitive performance



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J Nutr Health Aging. 2004;8(2):92-7. Related Articles, Links

Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and
dietary deficiencies in mice.

Rogers EJ, Milhalik S, Orthiz D, Shea TB.

Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences,
University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, Tel: 978-934-2881, Fax:
978-934-3044, Email: [email protected]

Increased oxidative stress contributes to the decline in cognitive performance during normal aging
and in neurodegenerative conditions such as Alzheimer s disease. Dietary supplementation with fruits
and vegetables that are high in antioxidant potential have in some cases compensated for dietary
and/or genetic deficiencies that promote increased oxidative stress. Herein, we demonstrate that
apple juice concentrate, administered ad libitum in drinking water, can compensate for the increased
reactive oxygen species and decline in cognitive performance in maze trials observed when normal and
transgenic mice lacking apolipoprotein E are deprived of folate and vitamin E. In addition, we
demonstrate that this protective effect is not derived from the sugar content of the concentrate.

PMID: 14978604 [PubMed - in process]

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