Armstrong's DNA

Discussion in 'Road Cycling' started by B. Lafferty, May 16, 2003.

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  1. B. Lafferty

    B. Lafferty Guest

    This is a multi-part message in MIME format.

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    Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But = will Lance say thank you to
    the "DNA donor" who is his biological = father?

    Brian--accept no substitutes--Lafferty Dear, you cannot drink gin and tonic in the middle of the
    night.=20 You must have whisky to give you energy. --Margaret Thatcher
    ------=_NextPart_000_0008_01C31B9A.051854A0 Content-Type: text/html; charset="Windows-1252"
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    http-equiv=3DContent-Type content=3D"text/html; = charset=3Dwindows-1252"> <META content=3D"MSHTML
    6.00.2800.1170" name=3DGENERATOR> <STYLE></STYLE> </HEAD> <BODY>
    <DIV><FONT face=3D"Comic Sans MS" size=3D2>Ah, the irony. Lance's = Subaru=20 commercial
    tells us it's in the DNA. But will Lance say thank = you to=20 the "DNA donor" who
    is his biological father?</FONT></DIV>
    <DV><FONT face=3D"Comic Sans MS" size=3D2></FONT> </DIV>
    <DVI><FONT face=3D"Comic Sans MS" size=3D2>Brian--accept no=20 substitutes--Lafferty</FONT></DIV>
    <DVII><FONT size=3D2>Dear, you cannot drink gin and tonic in the middle = of the=20 night. <BR>You
    must have whisky to give you energy.<BR>--Margaret=20 Thatcher</FONT></DIV></BODY></HTML>

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  2. Andy Coggan

    Andy Coggan Guest

    "B. Lafferty" <[email protected]> wrote in message
    news:z%[email protected]...

    > Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
    will Lance say thank you to the "DNA donor" who is his biological father?

    Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.

    Andy Coggan
     
  3. Amh

    Amh Guest

    "B. Lafferty" <[email protected]> wrote in message
    news:<z%[email protected]>...
    > Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But will Lance say thank you to
    > the "DNA donor" who is his biological father?

    He said "thank you" to the guy who gave him his Subaru paycheck though.

    Andy

    >
    > Brian--accept no substitutes--Lafferty Dear, you cannot drink gin and tonic in the middle of the
    > night. You must have whisky to give you energy. --Margaret Thatcher
    > --
     
  4. Sam

    Sam Guest

    Damn, beat me to it!

    "Andy Coggan" <[email protected]> wrote in message
    news:[email protected]...
    > "B. Lafferty" <[email protected]> wrote in message
    > news:z%[email protected]...
    >
    > > Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
    > will Lance say thank you to the "DNA donor" who is his biological father?
    >
    >
    > Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
    >
    > Andy Coggan
     
  5. Kyle Legate

    Kyle Legate Guest

    Andy Coggan wrote:
    > "B. Lafferty" <[email protected]> wrote in message
    > news:z%[email protected]...
    >
    >> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
    > will Lance say thank you to the "DNA donor" who is his biological father?
    >
    >
    > Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
    >
    Most mitochondrial proteins are encoded by nuclear DNA.
     
  6. Andy Coggan

    Andy Coggan Guest

    "Kyle Legate" <[email protected]> wrote in message
    news:[email protected]...
    > Andy Coggan wrote:
    > > "B. Lafferty" <[email protected]> wrote in message
    > > news:z%[email protected]...
    > >
    > >> Ah, the irony. Lance's Subaru commercial tells us it's in the DNA. But
    > > will Lance say thank you to the "DNA donor" who is his biological father?
    > >
    > >
    > > Maybe he doesn't really need to - he got all of his mitochondrial DNA from his mother.
    > >
    > Most mitochondrial proteins are encoded by nuclear DNA.

    True. But w/o the mitochondrial contribution, you can't make properly functioning
    mitochondria...hence (apparently) the presence of "ragged red fibers" in certain neuromuscular
    diseases, in the elderly, in peripheral vascular disease, etc.

    Andy Coggan
     
  7. Kyle Legate

    Kyle Legate Guest

    Andy Coggan wrote:
    > "Kyle Legate" <[email protected]> wrote in message
    > news:[email protected]...
    >>>
    >> Most mitochondrial proteins are encoded by nuclear DNA.
    >
    > True. But w/o the mitochondrial contribution, you can't make properly functioning
    > mitochondria...hence (apparently) the presence of "ragged red fibers" in certain neuromuscular
    > diseases, in the elderly, in peripheral vascular disease, etc.
    >
    Of course both genetic contributions are crucial for properly functioning mitochondria, but without
    the nuclear component mice don't even make it to birth.

    eg,

    Chen et al, Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential
    for embryonic development. J Cell Biol. 2003 Jan 20;160(2):189-200.

    Di Pietro et al, Mitochondrial NAD-dependent methylenetetrahydrofolate
    dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development. Mol
    Cell Biol. 2002 Jun;22(12):4158-66.
     
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