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Article] Scientists Take DNA's Temperature

Started by Robert Karl Sto · · Last activity · 3 posts · 494 views

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General fitness, health and nutrition
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30 December 2003
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  1. Scientists Take DNA's Temperature

    The temperature most often associated with human life is 98.6 degrees Fahrenheit, that of a healthy
    person. Now scientists have succeeded in taking a different measurement, one they've dubbed the
    "heat of life:" the energies involved in DNA replication and synthesis.

    Kenneth J. Breslauer of Rutgers University and his colleagues used an ultrasensitive calorimeter to
    measure the miniscule reaction heats associated with DNA synthesis in Escherichia coli. The team
    isolated a specific section of DNA and labeled parts with radioactive markers. The thermal detection
    system, which is accurate to a millionth of a calorie, determined the amount of heat given off when
    a base pair was inserted into the DNA strand. According to the report, which is published online
    this week by the Proceedings of the National Academy of Sciences, the amount of energy involved
    depends on which base pair is inserted into the strand. "Our measurements represent the first direct
    determination of the energies and their transformations in this most fundamental process in
    biological chemistry," Breslauer says.

    Read the rest at Scientific American tinyurl.comwjmc

    Comment: The latest science? Then why do they use a scale that was originally the measure of a
    King's stride (yard) foot (foot) or manliness (inch)?? Why not use the centigrade scale (Celsius)
    like the rest of the non-monarchical world (or do you Americans still check imperial measures
    against, say, the latest president's dimensions?)

    Kind Regards, Robert Karl Stonjek.

  2. "Robert Karl Stonjek" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:

    Scientists Take DNA's Temperature

    The temperature most often associated with human life is 98.6 degrees Fahrenheit, that of a
    healthy person. Now scientists have succeeded in taking a different measurement, one they've
    dubbed the "heat of life:" the energies involved in DNA replication and synthesis.


    [snip]

    Quoted message said:

    The thermal detection system, which is accurate to a millionth of a calorie, determined the amount
    of heat given off when a base pair was inserted into the DNA strand.


    [snip]

    Quoted message said:

    Comment: The latest science? Then why do they use a scale that was originally the measure of a
    King's stride (yard) foot (foot) or manliness (inch)?? Why not use the centigrade scale (Celsius)
    like the rest of the non-monarchical world (or do you Americans still check imperial measures
    against, say, the latest president's dimensions?)

    Kind Regards, Robert Karl Stonjek.

    It is interesting that the number 98.6, which every American school child learns, is a direct
    conversion from the Celsius estimate of 37 degrees that was set back in the 19th century by a German
    researcher. I suspect that Americans probably relied on an Oxbridge trained Englishman to do the
    arithmetic of the conversion - an American would have rounded to 99 degrees (and incidentally have
    come closer to the truth).

    Of course, Americans are familiar with some metric scales - notice that the heat measurement was in
    calories. Perhaps Scientific American should have converted that to BTU... ;-)

  3. [email hidden] (Jim Menegay) wrote in message news:<[email hidden]>...

    Quoted message said:

    "Robert Karl Stonjek" <[email hidden]> wrote in message
    news:<[email hidden]>...

    Quoted message said:

    Scientists Take DNA's Temperature

    The temperature most often associated with human life is 98.6 degrees Fahrenheit, that of a
    healthy person. Now scientists have succeeded in taking a different measurement, one they've
    dubbed the "heat of life:" the energies involved in DNA replication and synthesis.


    [snip]

    Quoted message said:

    The thermal detection system, which is accurate to a millionth of a calorie, determined the
    amount of heat given off when a base pair was inserted into the DNA strand.


    [snip]

    Quoted message said:

    Comment: The latest science? Then why do they use a scale that was originally the measure of a
    King's stride (yard) foot (foot) or manliness (inch)?? Why not use the centigrade scale
    (Celsius) like the rest of the non-monarchical world (or do you Americans still check imperial
    measures against, say, the latest president's dimensions?)

    Kind Regards, Robert Karl Stonjek.

    It is interesting that the number 98.6, which every American school child learns, is a direct
    conversion from the Celsius estimate of 37 degrees that was set back in the 19th century by a
    German researcher. I suspect that Americans probably relied on an Oxbridge trained Englishman to
    do the arithmetic of the conversion - an American would have rounded to 99 degrees (and
    incidentally have come closer to the truth).

    No, it would have been closer by truncating to 98 °F.

    Quoted message said:

    Of course, Americans are familiar with some metric scales - notice that the heat measurement was
    in calories. Perhaps Scientific American should have converted that to BTU... ;-)

    Scientific American should indeed have converted it. Calories are not part of the modern metric
    system. They are not part of the International System of Units (SI), and they are not part of the
    "metric system" as defined in U.S. law. The proper units are joules.

    Note also that they didn't use the metric prefixes, saying "millionth of a calorie" instead, and
    they didn't identify which calorie is being used--I'd say it should be the large calorie most often
    used in the medical field, but it might be the small calorie which was common in physics and
    chemistry, only 0.001 large calorie. Is the resolution of this equipment 4 mJ or is it 4 µJ?

    --
    Gene Nygaard ourworld.compuserve.comt jeff.htm But if it be thought
    that, either now, or at any future time, the citizens of the United States may be induced to
    undertake a thorough reformation of their whole system of measures, weights and coins, reducing
    every branch to the same decimal ratio already established in their coins, and thus bringing the
    calculation of the principal affairs of life within the arithmetic of every man who can multiply
    and divide plain numbers, greater changes will be necessary. U.S. Secretary of State Thomas
    Jefferson, 1790

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