asthma / iron / acidosis

Discussion in 'Health and medical' started by doe, Mar 7, 2004.

  1. doe

    doe Guest

    What relationship could? .. ph / acidosis have on the frequency / severity of
    asthma attacks?

    It has been shown and extensively used .. ph .. in the Intensive Care Unit ..
    in those with acute asthma attacks are 'treated' with injection of bicarbonate
    of soda.

    This is a 'base' / alkaline which in theory would raise the ph of the body
    'back into' a state of .. normal.

    Would / could this ph change BE .. related .. to the fact of elevated iron
    levels recently shown to BE in children with asthma?

    And HOW is this related to this study ?

    This study shows anaphylactic shock is related somehow TO the 'saturation' OF
    the iron complexes.

    So in those WITH iron excess .. as in the study below .. acidic conditions NOW
    allow for the 'spillage' of iron .. would / could the SAME occur in those with

    acidosis temporarily disrupts the capacity of transferrin to bind iron

    Diabetes. 1982 Dec;31(12):1109-14. Related Articles, Links

    A mechanism of susceptibility to mucormycosis in diabetic ketoacidosis:
    transferrin and iron availability.

    Artis WM, Fountain JA, Delcher HK, Jones HE.

    The defect in host defense that makes the diabetic ketoacidotic (DKA) patient
    susceptible to mucormycosis has not been identified. Sera from 10 DKA patients
    and three normal volunteers were tested for their capacity to support the in
    vitro growth of a common etiologic agent of mucormycosis, Rhizopus oryzae.
    After equilibration with room air none of the normal or DKA sera, each of which
    was now extremely alkaline, supported growth of R. oryzae. When the sera were
    placed in a CO2 atmosphere that permitted simulation of the in vivo clinical pH
    (normal 7.40 and DKA 7.3-6.6), four of seven DKA sera supported profuse fungal
    growth. No growth occurred in normal serum. The three DKA sera that did not
    support fungal growth at pH less than or equal to 7.3 contained less iron (x =
    13 micrograms/dl) than the four sera that supported profuse fungal growth (x =
    69 micrograms/dl). Increasing the iron content of iron-poor DKA serum that did
    not support R. oryzae growth allowed profuse growth at acidotic conditions but
    not at pH greater than or equal to 7.4. Simulated acidotic conditions (pH
    7.3-6.6) also decreased the iron-binding capacity of normal serum stepwise from
    266 micrograms/dl to 0. Our data indicate that acidosis temporarily disrupts
    the capacity of transferrin to bind iron and suggest that this alteration
    abolishes an important host defense mechanism that permits growth of R. oryzae.

    PMID: 6816646 [PubMed - indexed for MEDLINE]


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