<<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
As in most of your posts involving iron, it must be noted that it would be very surprising if iron was not involved in many of the bodies processes. Iron is absolutely critical for proper and optimal health, in addition to it's well known role in transporting oxygen to cells in the blood, there are several other critical roles it plays. Here is one: " Antioxidant and beneficial pro-oxidant functions Catalase and peroxidases are heme-containing enzymes that protect cells against the accumulation of hydrogen peroxide, a potentially converts hydrogen peroxide to to water and oxygen. As part of the immune response, some white blood cells engulf bacteria and expose them to ROS in order to kill them. The synthesis of one such ROS, hypochlorous acid, by neutrophils is catalyzed by the heme- containing enzyme myeloperoxidase (3, 4)." http://lpi.oregonstate.edu/infocenter/minerals/iron/index.h- tml As time goes on, we will explore other roles iron plays in proper and optimal health. It is well and good that you bring the value of iron to our attention and we look forward to a joint effort in education in this regard.
>Subject: Re: atherosclerosis / iron >From: [email protected] <<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Tom, if you are going to be both fair and honest, all sides and functions about the roles of iron in normal health and disease prevention need be discusssed. As posted, iron in some of it's functions acts as an antioxident and disease prevention tool to kill germs.
>Subject: Re: atherosclerosis / iron >From: [email protected] >Date: 3/9/2004 10:48 AM Mountain Standard Time >Message-id: <[email protected]> > >Tom, if you are going to be both fair and honest, all sides >and functions about the roles of iron in normal health and >disease prevention need be discusssed. As posted, iron in >some of it's functions acts as an antioxident and disease >prevention tool to kill germs. > Go do it then .. somewhere .. else .. <<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
"Go do it then .. somewhere .. else .." Tom, is the above to say this is your personal ng and that research to the contrary of your theory is not welcome? Or, does it mean you are not, as in the original, interested in being fair or honest in the presentation of information?
>Subject: Re: atherosclerosis / iron >From: [email protected] >Date: 3/10/2004 7:50 AM Mountain Standard Time >Message-id: <[email protected]> > >"Go do it then .. somewhere .. else .." > >Tom, is the above to say this is your personal ng and that >research to the contrary of your theory is not welcome? Or, >does it mean you are not, as in the original, interested in >being fair or honest in the presentation of information? It means .. start your own stupid thread .. You can't even spell antioxidant and expect to be able to speak TO .. antioxidants .. ? You .. are .. a .. fkg .. idiot .. <<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Tom, is the above to say this is your personal ng and that research to the contrary of your theory is not welcome? Or, does it mean you are not, as in the original, interested in being fair or honest in the presentation of information? Fkg, is your spell check on the blink, this isn't in my dictionary, or you being just a wee bit naughty on us here Tom?
>Subject: Re: atherosclerosis / iron >From: [email protected] >Date: 3/11/2004 7:42 AM Mountain Standard Time >Message-id: <[email protected]> > >Tom, is the above to say this is your personal ng and that >research to the contrary of your theory is not welcome? Or, >does it mean you are not, as in the original, interested in >being fair or honest in the presentation of information? > >Fkg, is your spell check on the blink, this isn't in my >dictionary, or you being just a wee bit naughty on us >here Tom? > > > It means .. start your own stupid thread .. You can't even spell antioxidant and expect to be able to speak TO .. antioxidants .. ? You .. are .. a .. fkg .. idiot .. <<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
Tom, go in peace. May you find what ever it is you seek in this world and may God bless and protect you.
>Subject: Re: atherosclerosis / iron >From: [email protected] >Date: 3/11/2004 3:14 PM Mountain Standard Time >Message-id: <[email protected]> > >Tom, go in peace. May you find what ever it is you seek in >this world and may God bless and protect you. > > > > > It means .. start your own stupid thread .. You can't even spell antioxidant and expect to be able to speak TO .. antioxidants .. ? You .. are .. a .. fkg .. idiot .. <<snip>> iron accumulates in human lesions <<snip>> Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of print] Links Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper. Stadler N, Lindner RA, Davies MJ. The Heart Research Institute, Sydney, Australia. OBJECTIVE: The involvement of transition metals in atherosclerosis is controversial. Some epidemiological studies have reported a relationship between iron (Fe) and cardiovascular disease, whereas others have not. Experimental studies have reported elevated levels of iron and copper (Cu) in diseased human arteries but have often used methods that release metal ions from proteins. METHODS AND RESULTS: In this study, we have used the minimally invasive technique of electron paramagnetic resonance (EPR) spectroscopy and inductively coupled plasma mass spectroscopy (ICPMS) to quantify iron and copper in ex vivo healthy human arteries and carotid lesions. The EPR spectra detected are characteristic of nonheme Fe(III) complexes. Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls (0.370 versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168 nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively, P<0.05). Iron levels did not correlate with the gender or age of the donor, or tissue protein or calcium levels, but cholesterol levels correlated positively with iron accumulation, as measured by EPR. CONCLUSIONS: These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression. PMID: 15001454 [PubMed - as supplied by publisher] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
