atherosclerosis / iron



D

Doe

Guest
<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
As in most of your posts involving iron, it must be noted
that it would be very surprising if iron was not involved in
many of the bodies processes. Iron is absolutely critical
for proper and optimal health, in addition to it's well
known role in transporting oxygen to cells in the blood,
there are several other critical roles it plays. Here is
one: " Antioxidant and beneficial pro-oxidant functions

Catalase and peroxidases are heme-containing enzymes that
protect cells against the accumulation of hydrogen
peroxide, a potentially converts hydrogen peroxide to to
water and oxygen. As part of the immune response, some
white blood cells engulf bacteria and expose them to ROS
in order to kill them. The synthesis of one such ROS,
hypochlorous acid, by neutrophils is catalyzed by the heme-
containing enzyme myeloperoxidase (3, 4)."

http://lpi.oregonstate.edu/infocenter/minerals/iron/index.h-
tml

As time goes on, we will explore other roles iron plays in
proper and optimal health. It is well and good that you
bring the value of iron to our attention and we look forward
to a joint effort in education in this regard.
 
>Subject: Re: atherosclerosis / iron
>From: [email protected]

<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
Tom, if you are going to be both fair and honest, all sides
and functions about the roles of iron in normal health and
disease prevention need be discusssed. As posted, iron in
some of it's functions acts as an antioxident and disease
prevention tool to kill germs.
 
>Subject: Re: atherosclerosis / iron
>From: [email protected]
>Date: 3/9/2004 10:48 AM Mountain Standard Time
>Message-id: <[email protected]>
>
>Tom, if you are going to be both fair and honest, all sides
>and functions about the roles of iron in normal health and
>disease prevention need be discusssed. As posted, iron in
>some of it's functions acts as an antioxident and disease
>prevention tool to kill germs.
>

Go do it then .. somewhere .. else ..

<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
"Go do it then .. somewhere .. else .."

Tom, is the above to say this is your personal ng and that
research to the contrary of your theory is not welcome? Or,
does it mean you are not, as in the original, interested in
being fair or honest in the presentation of information?
 
>Subject: Re: atherosclerosis / iron
>From: [email protected]
>Date: 3/10/2004 7:50 AM Mountain Standard Time
>Message-id: <[email protected]>
>
>"Go do it then .. somewhere .. else .."
>
>Tom, is the above to say this is your personal ng and that
>research to the contrary of your theory is not welcome? Or,
>does it mean you are not, as in the original, interested in
>being fair or honest in the presentation of information?

It means .. start your own stupid thread ..

You can't even spell antioxidant and expect to be able to
speak TO .. antioxidants .. ?

You .. are .. a .. fkg .. idiot ..

<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
Tom, is the above to say this is your personal ng and that
research to the contrary of your theory is not welcome? Or,
does it mean you are not, as in the original, interested in
being fair or honest in the presentation of information?

Fkg, is your spell check on the blink, this isn't in
my dictionary, or you being just a wee bit naughty on
us here Tom?
 
>Subject: Re: atherosclerosis / iron
>From: [email protected]
>Date: 3/11/2004 7:42 AM Mountain Standard Time
>Message-id: <[email protected]>
>
>Tom, is the above to say this is your personal ng and that
>research to the contrary of your theory is not welcome? Or,
>does it mean you are not, as in the original, interested in
>being fair or honest in the presentation of information?
>
>Fkg, is your spell check on the blink, this isn't in my
>dictionary, or you being just a wee bit naughty on us
>here Tom?
>
>
>

It means .. start your own stupid thread ..

You can't even spell antioxidant and expect to be able to
speak TO .. antioxidants .. ?

You .. are .. a .. fkg .. idiot ..

<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
Tom, go in peace. May you find what ever it is you seek in
this world and may God bless and protect you.
 
>Subject: Re: atherosclerosis / iron
>From: [email protected]
>Date: 3/11/2004 3:14 PM Mountain Standard Time
>Message-id: <[email protected]>
>
>Tom, go in peace. May you find what ever it is you seek in
>this world and may God bless and protect you.
>
>
>
>
>

It means .. start your own stupid thread ..

You can't even spell antioxidant and expect to be able to
speak TO .. antioxidants .. ?

You .. are .. a .. fkg .. idiot ..

<<snip>> iron accumulates in human lesions <<snip>>

Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
print] Links

Direct Detection and Quantification of Transition Metal Ions
in Human Atherosclerotic Plaques: Evidence for the Presence
of Elevated Levels of Iron and Copper.

Stadler N, Lindner RA, Davies MJ.

The Heart Research Institute, Sydney, Australia.

OBJECTIVE: The involvement of transition metals in
atherosclerosis is controversial. Some epidemiological
studies have reported a relationship between iron (Fe) and
cardiovascular disease, whereas others have not.
Experimental studies have reported elevated levels of iron
and copper (Cu) in diseased human arteries but have often
used methods that release metal ions from proteins. METHODS
AND RESULTS: In this study, we have used the minimally
invasive technique of electron paramagnetic resonance (EPR)
spectroscopy and inductively coupled plasma mass
spectroscopy (ICPMS) to quantify iron and copper in ex vivo
healthy human arteries and carotid lesions. The EPR spectra
detected are characteristic of nonheme Fe(III) complexes.
Statistically elevated levels of iron were detected in the
intima of lesions compared with healthy controls (0.370
versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
levels of copper were also detected (7.51 versus 2.01
pmol/mg tissue, lesion versus healthy control, respectively,
P<0.05). Iron levels did not correlate with the gender or
age of the donor, or tissue protein or calcium levels, but
cholesterol levels correlated positively with iron
accumulation, as measured by EPR. CONCLUSIONS: These data
support the hypothesis that iron accumulates in human
lesions and may contribute to disease progression.

PMID: 15001454 [PubMed - as supplied by publisher]

------------------------------------------------------------
--------------
------

Who loves ya. Tom Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD
PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
You must log in or register to reply here.
Top Bottom Back