atherosclerosis / iron

Discussion in 'Health and medical' started by Doe, Mar 8, 2004.

  1. Doe

    Doe Guest

    <<snip>> iron accumulates in human lesions <<snip>>

    Arterioscler Thromb Vasc Biol. 2004 Mar 4 [Epub ahead of
    print] Links

    Direct Detection and Quantification of Transition Metal Ions
    in Human Atherosclerotic Plaques: Evidence for the Presence
    of Elevated Levels of Iron and Copper.

    Stadler N, Lindner RA, Davies MJ.

    The Heart Research Institute, Sydney, Australia.

    OBJECTIVE: The involvement of transition metals in
    atherosclerosis is controversial. Some epidemiological
    studies have reported a relationship between iron (Fe) and
    cardiovascular disease, whereas others have not.
    Experimental studies have reported elevated levels of iron
    and copper (Cu) in diseased human arteries but have often
    used methods that release metal ions from proteins. METHODS
    AND RESULTS: In this study, we have used the minimally
    invasive technique of electron paramagnetic resonance (EPR)
    spectroscopy and inductively coupled plasma mass
    spectroscopy (ICPMS) to quantify iron and copper in ex vivo
    healthy human arteries and carotid lesions. The EPR spectra
    detected are characteristic of nonheme Fe(III) complexes.
    Statistically elevated levels of iron were detected in the
    intima of lesions compared with healthy controls (0.370
    versus 0.022 nmol/mg tissue for EPR, 0.525 versus 0.168
    nmol/mg tissue by ICPMS, P<0.05 in each cases). Elevated
    levels of copper were also detected (7.51 versus 2.01
    pmol/mg tissue, lesion versus healthy control, respectively,
    P<0.05). Iron levels did not correlate with the gender or
    age of the donor, or tissue protein or calcium levels, but
    cholesterol levels correlated positively with iron
    accumulation, as measured by EPR. CONCLUSIONS: These data
    support the hypothesis that iron accumulates in human
    lesions and may contribute to disease progression.

    PMID: 15001454 [PubMed - as supplied by publisher]

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