Since lecithin is KNOWN to 'melt fat' .. would / could one extrapolate the
animal studies TO this disease .. atherosclerosis .. ?
Thereby assuming SINCE in man .. lecithin melts fat .. would / could the
lecithin in man also melt .. atherosclerosis .. ?
As in the mouse ..
<<snip>>
dietary lecithin promotes removal of lipid from established atherosclerotic
plaque.
<<snip>>
Dermatol Surg. 2004 Mar;30(3):422-7; discussion 428. Related Articles, Links
Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial
and review.
Ablon G, Rotunda AM.
West Los Angeles Veteran Administration Medical Center, Los Angeles, CA, USA.
[email hidden]
BACKGROUND: Injectable phosphatidylcholine, a lecithin-derived phospholipid,
has been previously demonstrated to improve the appearance of infraorbital fat
pad herniation. Current use internationally has led to a significant interest
in this novel substance. OBJECTIVE: To evaluate the efficacy and safety of
injectable phosphatidylcholine, we conducted an open-label study for the
treatment of infraorbital fat pad herniation. METHODS: Patients received 0.4-mL
phosphatidylcholine (50 mg/mL) injections within infraorbital fat pads every 2
weeks. Patient and physician grading of fat herniation, side effects, digital
photographs, and a follow-up questionnaire was recorded. RESULTS: Ten of the 13
enrolled patients had three to five treatments. Improvements in fat herniation
were reported in 80% and 70% of patients as graded by the physician and
patients, respectively. Sixty percent of patients assessed their improvement as
equal or greater than 5 points (on a 10-point fat herniation scale); however,
the physician judged 40% of patients improving to this degree. Little or no
response was seen in three patients. Side effects included burning, erythema,
and swelling at the injection site. At follow-up averaging 9 months, 50% of
patients reported persistence of benefit, 20% experienced some fading, and 30%
were the nonresponders. CONCLUSIONS: Injectable phosphatidylcholine is a novel
treatment for infraorbital fat herniation that may benefit some patients who
are considering blepharoplasty. Larger studies evaluating long-term safety and
efficacy of phosphatidylcholine for cosmetic purposes are warranted.
PMID: 15008874 [PubMed - in process]
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Br J Exp Pathol 1985 Feb;66(1):35-46
Hyperlipoproteinaemia and atherosclerosis in rabbits fed low-level cholesterol
and lecithin.
Hunt CE, Duncan LA
Dutch-Belted rabbits were fed for 18 months an atherogenic semipurified gel
diet containing 14% hydrogenated coconut oil and 0.06% cholesterol
(approximately 0.15 mg/kcal) or a non-atherogenic basal gel diet containing the
same ingredients but with no coconut oil or cholesterol. Rabbits fed
atherogenic diet developed hypercholesterolaemia (means 733 mg/dl at 16 months)
and plasma lipoprotein (LP) distribution shifted from a pattern in which
high-density lipoproteins (HDL) predominated to one in which very-low-density
lipoproteins (VLDL) were predominant. Total cholesterol/triglyceride ratio in d
less than 1.006 LP changed from 0.3 to 1.8. Plasma cholesterol and LP
distribution returned to normal in rabbits fed atherogenic diet for 18 months
followed by atherogenic diet plus 3% soya lecithin for an additional 4 months.
Rabbits fed atherogenic diet for 18 months had extensive, usually full
circumference fibromuscular plaques in main branches of coronary arteries and
all portions of aorta which compromised lumen area by almost 50%. These lesions
were modified in rabbits fed atherogenic diet plus lecithin. The plaques lacked
foam cells and cholesterol clefts, were less cellular with a distinct fibrous
surface and occupied less space. Animals fed basal diet did not develop
hypercholesterolaemia (means 86 mg/dl at 16 months), although distribution of
plasma LP shifted slightly in favour of increased low-density lipoproteins
(LDL) and decreased HDL compared with rabbits fed standard commercial diet.
Basal diet rabbits had no coronary atherosclerosis and only minimal focal foam
cell lesions in proximal aorta. Liver injury including fatty change,
cholangitis and portal fibrosis occurred in animals fed atherogenic diet. Thus,
rabbits fed appropriate diets low in cholesterol accumulate
cholesterol-enriched LP in their plasma and develop lesions in abdominal aorta
and main branches of coronary arteries which are similar to those in man. Also,
in this experimental model, dietary lecithin promotes a return to normal of the
LP distribution profile and removal of lipid from established atherosclerotic
plaque.
PMID: 3970829, UI: 85122459
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