avocado for liver damage

Discussion in 'Health and medical' started by Toby Jones, Mar 2, 2004.

  1. Toby Jones

    Toby Jones Guest

    Liver injury suppressing compounds from avocado (Persea americana).

    Kawagishi H, Fukumoto Y, et al

    Department of Applied Biochemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka
    422-8529, Japan.

    To evaluate the protective activity of fruits against liver injury, 22 different fruits were fed to
    rats with liver damage caused by D-galactosamine, a powerful liver toxin.

    As measured by changes in the levels of plasma alanine aminotransferase (ALT) and aspartate
    aminotransferase (AST), avocado showed extraordinarily potent liver injury suppressing activity.

    Five active compounds were isolated and their structures determined. These were all fatty acid
    derivatives, of which three, namely, (2E,5E,12Z,15Z)-1-hydroxyheneicosa-2,5,12,15-tetraen-4-one, (2E,12Z,15Z)-1-hydroxyheneicosa-2,12,15-trien-4-
    one, and (5E,12Z)-2-hydroxy-4-oxoheneicosa-5,12-dien-1-yl acetate, were novel.

    J Agric Food Chem. 2001 May;49(5):2215-21. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrie-