General fitness, health and nutrition · Public discussion

Bisphosphonates and Cardiovascular Disease

Started by Lou Pagnucco · · Last activity · 2 posts · 430 views

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General fitness, health and nutrition
Published
29 April 2004
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29 April 2004
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Lou Pagnucco
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  1. A study in the journal "Circulation" finds that the level of
    the bone density regulator, osteoprotegerin, is strongly
    predictive of cardiovascular disease and stroke. See:

    "Bone Builder Linked to Heart Disease"
    healthday.comview.cfm

    Osteoprotegerin levels may be increased by bisphosphonates
    typically prescribed for osteoporosis. See:

    "Bisphosphonates Pamidronate and Zoledronate stimulate
    Osteoprotegerin Production by Primary Human Osteoblasts"
    thieme.dedaten
    /v048.html

    This raises the question whether bisphosphonates may
    increase the risk of vascular disease.

    Any comments?

  2. "Lou Pagnucco" <[email hidden]> wrote in message
    "]news:[email hidden]...

    Quoted message said:

    A study in the journal "Circulation" finds that the
    level of the bone density regulator, osteoprotegerin, is
    strongly predictive of cardiovascular disease and
    stroke. See:

    "Bone Builder Linked to Heart Disease"
    healthday.comview.cfm

    Osteoprotegerin levels may be increased by bisphosphonates
    typically prescribed for osteoporosis. See:

    "Bisphosphonates Pamidronate and Zoledronate stimulate
    Osteoprotegerin Production by Primary Human Osteoblasts"
    thieme.dev
    048.html

    This raises the question whether bisphosphonates may
    increase the risk of vascular disease.

    Any comments?

    That's possible. Though I was thinking it could also be the
    other way around. Could statins lower bone mass density as
    an offshoot of their cardio-protective effect? I've been
    taking statins for several years and, despite taking
    Fosomax, have been seeing a decrease in BMD. (I realize this
    is just one case, so it is just a question.)

    Bill

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