bisphosphonates / iron chelating

Discussion in 'Food and nutrition' started by Doe, Jan 27, 2004.

  1. Doe

    Doe Guest

    >>snip<<
    In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
    properties of the bisphosphonates are due to their iron chelating characteristics.
    >>snip<<

    Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links

    Selective in vitro antioxidant properties of bisphosphonates.

    Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.

    Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
    Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium

    The aim of this study was to investigate the in vitro antioxidant profile of different
    bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
    peroxidation inhibiting capacity. Furthermore, the effect of these different compounds on DPPH, a
    stable radical, was investigated. Clodronate, risedronate, and pyrophosphate were further tested for
    their hydroxyl radical scavenging activity. None of the tested compounds showed xanthine oxidase
    inhibiting activity or DPPH scavenging activity. All the tested bisphosphonates exhibited inhibiting
    capacities on the microsomal lipid peroxidation. The hydroxyl radical scavenging activity was
    dependent on the order of adding the different reagents and was highest for risedronate.
    Bisphosphonates possess an inhibiting activity on the microsomal lipid peroxidation and the Fenton
    reaction. In these reactions iron plays an important role suggesting that the selective in vitro
    antioxidant properties of the bisphosphonates are due to their iron chelating characteristics.

    PMID: 14741688 [PubMed - in process]

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