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>>snip<<
In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
properties of the bisphosphonates are due to their iron chelating characteristics.
>>snip<<
Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links
Selective in vitro antioxidant properties of bisphosphonates.
Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.
Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium
The aim of this study was to investigate the in vitro antioxidant profile of different
bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
peroxidation inhibiting capacity. Furthermore, the effect of these different compounds on DPPH, a
stable radical, was investigated. Clodronate, risedronate, and pyrophosphate were further tested for
their hydroxyl radical scavenging activity. None of the tested compounds showed xanthine oxidase
inhibiting activity or DPPH scavenging activity. All the tested bisphosphonates exhibited inhibiting
capacities on the microsomal lipid peroxidation. The hydroxyl radical scavenging activity was
dependent on the order of adding the different reagents and was highest for risedronate.
Bisphosphonates possess an inhibiting activity on the microsomal lipid peroxidation and the Fenton
reaction. In these reactions iron plays an important role suggesting that the selective in vitro
antioxidant properties of the bisphosphonates are due to their iron chelating characteristics.
PMID: 14741688 [PubMed - in process]
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Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
properties of the bisphosphonates are due to their iron chelating characteristics.
>>snip<<
Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links
Selective in vitro antioxidant properties of bisphosphonates.
Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.
Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium
The aim of this study was to investigate the in vitro antioxidant profile of different
bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
peroxidation inhibiting capacity. Furthermore, the effect of these different compounds on DPPH, a
stable radical, was investigated. Clodronate, risedronate, and pyrophosphate were further tested for
their hydroxyl radical scavenging activity. None of the tested compounds showed xanthine oxidase
inhibiting activity or DPPH scavenging activity. All the tested bisphosphonates exhibited inhibiting
capacities on the microsomal lipid peroxidation. The hydroxyl radical scavenging activity was
dependent on the order of adding the different reagents and was highest for risedronate.
Bisphosphonates possess an inhibiting activity on the microsomal lipid peroxidation and the Fenton
reaction. In these reactions iron plays an important role suggesting that the selective in vitro
antioxidant properties of the bisphosphonates are due to their iron chelating characteristics.
PMID: 14741688 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking