Blood pressure / oxidative stress



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J Nutr Biochem. 2004 Jun;15(6):323-327. Related Articles, Links

Effect on rat arterial blood pressure of chemically
generated peroxyl radicals and protection by antioxidants.

Peluso I, Serafini M, Campolongo P, Palmery M.

Department of Pharmacology of Natural Substances and General
Physiology, "La Sapienza" University, P.le Aldo Moro 5,
00185 Rome, Italy.

Convincing evidence suggests that blood redox changes play a
role in the development of various cardiovascular disorders
including hypertension. Nutritional antioxidants have been
suggested to play a role in cardiovascular disease
prevention. In this study, we investigated in vivo changes
in rat arterial blood pressure induced by acute exposition
to an increased load of peroxyl radicals and by the
administration of selected antioxidants after chemically
induced oxidative stress. Hydrosoluble and liposoluble
peroxyl radicals, generated by 2,2'-azobis-(2-
amidinopropane) dihydrochloride and 2,2'-azobis 2,4-di-
methylvaleronitrile, induced a dose-dependent decrease in
rat blood pressure. All antioxidants tested (6-hydroxy-2,5,7,8-tetramethylchroman-2-
carboxylic acid, vitamin C, glutathione and dithiothreitol)
returned peroxyl radical-induced hypotension to normal. Of
the various antioxidants tested, glutathione was the most
effective in restoring blood pressure after peroxyl radical
generation. Treatment of rats with a thiol-chelating agent
(N-ethylmaleimide) and an oxidizing agent (5,5'-dithiobis-2-
nitrobenzoic) inhibited peroxyl radical-mediated
hypotension. Our results suggest that acute exposition to
peroxyl radicals have a hypotensive effect on blood pressure
and that thiols play an active role in the redox regulation
of blood pressure. Other experiments are needed to clarify
the role played by oxidative potentials on blood pressure
and the mechanism of action of nutritional antioxidants.

PMID: 15157937 [PubMed - as supplied by publisher]

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