Blood pressure / oxidative stress

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    J Nutr Biochem. 2004 Jun;15(6):323-327. Related Articles, Links

    Effect on rat arterial blood pressure of chemically
    generated peroxyl radicals and protection by antioxidants.

    Peluso I, Serafini M, Campolongo P, Palmery M.

    Department of Pharmacology of Natural Substances and General
    Physiology, "La Sapienza" University, P.le Aldo Moro 5,
    00185 Rome, Italy.

    Convincing evidence suggests that blood redox changes play a
    role in the development of various cardiovascular disorders
    including hypertension. Nutritional antioxidants have been
    suggested to play a role in cardiovascular disease
    prevention. In this study, we investigated in vivo changes
    in rat arterial blood pressure induced by acute exposition
    to an increased load of peroxyl radicals and by the
    administration of selected antioxidants after chemically
    induced oxidative stress. Hydrosoluble and liposoluble
    peroxyl radicals, generated by 2,2'-azobis-(2-
    amidinopropane) dihydrochloride and 2,2'-azobis 2,4-di-
    methylvaleronitrile, induced a dose-dependent decrease in
    rat blood pressure. All antioxidants tested (6-hydroxy-2,5,7,8-tetramethylchroman-2-
    carboxylic acid, vitamin C, glutathione and dithiothreitol)
    returned peroxyl radical-induced hypotension to normal. Of
    the various antioxidants tested, glutathione was the most
    effective in restoring blood pressure after peroxyl radical
    generation. Treatment of rats with a thiol-chelating agent
    (N-ethylmaleimide) and an oxidizing agent (5,5'-dithiobis-2-
    nitrobenzoic) inhibited peroxyl radical-mediated
    hypotension. Our results suggest that acute exposition to
    peroxyl radicals have a hypotensive effect on blood pressure
    and that thiols play an active role in the redox regulation
    of blood pressure. Other experiments are needed to clarify
    the role played by oxidative potentials on blood pressure
    and the mechanism of action of nutritional antioxidants.

    PMID: 15157937 [PubMed - as supplied by publisher]


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