JAMA. 2004 Feb 11;291(6):711-7. Related Articles, Links Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. [email protected] CONTEXT: Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a healthy population. OBJECTIVE: To examine plasma ferritin concentration and the ratio of the concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: Prospective nested case-control study within the Nurses' Health Study cohort. Of the 32 826 women who provided blood samples during 1989-1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The controls (n = 716) were matched to cases on age, race, and fasting status; and on body mass index (BMI) for cases in the top BMI decile. MAIN OUTCOME MEASURE: Incident cases of type 2 diabetes. RESULTS: Among cases, the mean (SD) concentration of ferritin was significantly higher (109 [105] vs 71.5 [68.7] ng/mL for controls; P<.001 for difference) and the mean (SD) ratio of transferrin receptors to ferritin was significantly lower (102 [205] vs 141 [340], respectively; P =.01). In conditional logistic regression stratified on the matching factors and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs] of incident type 2 diabetes across increasing quintiles of ferritin were 1.00, 1.09 (95% confidence interval [CI], .70-1.70), 1.26 (95% CI, 0.82-1.95), 1.30 (95% CI, 0.83-2.04), and 2.68 (95% CI, 1.75-4.11) (P<.001 for trend). The RRs across increasing quintiles of transferrin receptors to ferritin ratio were 2.44 (95% CI, 1.61-3.71), 1.00 (95% CI, 0.64-1.56), 1.13 (95% CI, 0.73-1.74), 0.99 (95% CI, 0.64-1.53), and 340.1 (A=.01 for trend). Further adjustment for an inflammatory marker (C-reactive protein) did not change the results appreciably. The associations persisted within strata defined by levels of BMI, menopausal status, alcohol consumption, and C-reactive protein. CONCLUSION: Higher iron stores (reflected by an elevated ferritin concentration and a lower ratio of transferrin receptors to ferritin) are associated with an increased risk of type 2 diabetes in healthy women independent of known diabetes risk factors. PMID: 14871914 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
>Subject: Body iron stores in healthy women. http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=4328316 >From: [email protected] (doe) Date: 2/12/2004 8:19 AM Mountain Standard Time Message-id: <[email protected] >m27.aol.com> > > JAMA. 2004 Feb 11;291(6):711-7. Related Articles, Links > > >Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. > >Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. > >Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. >[email protected] > >CONTEXT: Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload. >However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a >healthy population. OBJECTIVE: To examine plasma ferritin concentration and the ratio of the >concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. DESIGN, >SETTING, AND PARTICIPANTS: Prospective nested case-control study within the Nurses' Health Study >cohort. Of the 32 826 women who provided blood samples during 1989-1990 and were free of diagnosed >diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. >The controls (n = 716) were matched to cases on age, race, and fasting status; and on body mass >index (BMI) for cases in the top BMI decile. MAIN OUTCOME MEASURE: Incident cases of type 2 >diabetes. RESULTS: Among cases, the mean (SD) concentration of ferritin was significantly higher >(109 [105] vs 71.5 [68.7] ng/mL for controls; P<.001 for difference) and the mean (SD) ratio of >transferrin receptors to ferritin was significantly lower (102 [205] vs 141 >[340], respectively; P =.01). In conditional logistic regression stratified on the matching factors > and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs] > of incident type 2 diabetes across increasing quintiles of ferritin were 1.00, 1.09 (95% > confidence interval >[CI], .70-1.70), 1.26 (95% CI, 0.82-1.95), 1.30 (95% CI, 0.83-2.04), and 2.68 (95% CI, 1.75-4.11) > (P<.001 for trend). The RRs across increasing quintiles of transferrin receptors to ferritin > ratio were 2.44 (95% CI, 1.61-3.71), 1.00 (95% CI, 0.64-1.56), 1.13 (95% CI, 0.73-1.74), 0.99 > (95% CI, 0.64-1.53), and > 1.00 (P=.01 for trend). Further adjustment for an inflammatory marker (C-reactive protein) did not > change the results appreciably. The associations persisted within strata defined by levels > of BMI, menopausal status, alcohol consumption, and C-reactive protein. CONCLUSION: Higher > iron stores (reflected by an elevated ferritin concentration and a lower ratio of > transferrin receptors to ferritin) are associated with an increased risk of type 2 diabetes > in healthy women independent of known diabetes risk factors. > >PMID: 14871914 [PubMed - in process] > >-------------------------------------------------------------------------- >------ > >Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
