Body iron stores in healthy women.

Discussion in 'Health and medical' started by Doe, Feb 12, 2004.

  1. Doe

    Doe Guest

    JAMA. 2004 Feb 11;291(6):711-7. Related Articles, Links

    Body iron stores in relation to risk of type 2 diabetes in apparently healthy women.

    Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB.

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
    [email protected]

    CONTEXT: Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload.
    However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a
    healthy population. OBJECTIVE: To examine plasma ferritin concentration and the ratio of the
    concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. DESIGN,
    SETTING, AND PARTICIPANTS: Prospective nested case-control study within the Nurses' Health Study
    cohort. Of the 32 826 women who provided blood samples during 1989-1990 and were free of diagnosed
    diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up.
    The controls (n = 716) were matched to cases on age, race, and fasting status; and on body mass
    index (BMI) for cases in the top BMI decile. MAIN OUTCOME MEASURE: Incident cases of type 2
    diabetes. RESULTS: Among cases, the mean (SD) concentration of ferritin was significantly higher
    (109 [105] vs 71.5 [68.7] ng/mL for controls; P<.001 for difference) and the mean (SD) ratio of
    transferrin receptors to ferritin was significantly lower (102 [205] vs 141
    [340], respectively; P =.01). In conditional logistic regression stratified on the matching factors
    and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs]
    of incident type 2 diabetes across increasing quintiles of ferritin were 1.00, 1.09 (95%
    confidence interval [CI], .70-1.70), 1.26 (95% CI, 0.82-1.95), 1.30 (95% CI, 0.83-2.04), and
    2.68 (95% CI, 1.75-4.11) (P<.001 for trend). The RRs across increasing quintiles of transferrin
    receptors to ferritin ratio were 2.44 (95% CI, 1.61-3.71), 1.00 (95% CI, 0.64-1.56), 1.13 (95%
    CI, 0.73-1.74), 0.99 (95% CI, 0.64-1.53), and
    340.1 (A=.01 for trend). Further adjustment for an inflammatory marker (C-reactive protein) did not
    change the results appreciably. The associations persisted within strata defined by levels
    of BMI, menopausal status, alcohol consumption, and C-reactive protein. CONCLUSION: Higher
    iron stores (reflected by an elevated ferritin concentration and a lower ratio of
    transferrin receptors to ferritin) are associated with an increased risk of type 2 diabetes
    in healthy women independent of known diabetes risk factors.

    PMID: 14871914 [PubMed - in process]

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  2. Doe

    Doe Guest

    >Subject: Body iron stores in healthy women.

    http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=4328316

    >From: [email protected] (doe) Date: 2/12/2004 8:19 AM Mountain Standard Time Message-id: <[email protected]
    >m27.aol.com>
    >
    > JAMA. 2004 Feb 11;291(6):711-7. Related Articles, Links
    >
    >
    >Body iron stores in relation to risk of type 2 diabetes in apparently healthy women.
    >
    >Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB.
    >
    >Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
    >[email protected]
    >
    >CONTEXT: Type 2 diabetes is a common manifestation of hemochromatosis, a disease of iron overload.
    >However, it is not clear whether higher iron stores predict the development of type 2 diabetes in a
    >healthy population. OBJECTIVE: To examine plasma ferritin concentration and the ratio of the
    >concentrations of transferrin receptors to ferritin in relation to risk of type 2 diabetes. DESIGN,
    >SETTING, AND PARTICIPANTS: Prospective nested case-control study within the Nurses' Health Study
    >cohort. Of the 32 826 women who provided blood samples during 1989-1990 and were free of diagnosed
    >diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up.
    >The controls (n = 716) were matched to cases on age, race, and fasting status; and on body mass
    >index (BMI) for cases in the top BMI decile. MAIN OUTCOME MEASURE: Incident cases of type 2
    >diabetes. RESULTS: Among cases, the mean (SD) concentration of ferritin was significantly higher
    >(109 [105] vs 71.5 [68.7] ng/mL for controls; P<.001 for difference) and the mean (SD) ratio of
    >transferrin receptors to ferritin was significantly lower (102 [205] vs 141
    >[340], respectively; P =.01). In conditional logistic regression stratified on the matching factors
    > and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs]
    > of incident type 2 diabetes across increasing quintiles of ferritin were 1.00, 1.09 (95%
    > confidence interval
    >[CI], .70-1.70), 1.26 (95% CI, 0.82-1.95), 1.30 (95% CI, 0.83-2.04), and 2.68 (95% CI, 1.75-4.11)
    > (P<.001 for trend). The RRs across increasing quintiles of transferrin receptors to ferritin
    > ratio were 2.44 (95% CI, 1.61-3.71), 1.00 (95% CI, 0.64-1.56), 1.13 (95% CI, 0.73-1.74), 0.99
    > (95% CI, 0.64-1.53), and
    > 1.00 (P=.01 for trend). Further adjustment for an inflammatory marker (C-reactive protein) did not
    > change the results appreciably. The associations persisted within strata defined by levels
    > of BMI, menopausal status, alcohol consumption, and C-reactive protein. CONCLUSION: Higher
    > iron stores (reflected by an elevated ferritin concentration and a lower ratio of
    > transferrin receptors to ferritin) are associated with an increased risk of type 2 diabetes
    > in healthy women independent of known diabetes risk factors.
    >
    >PMID: 14871914 [PubMed - in process]
    >
    >--------------------------------------------------------------------------
    >------
    >
    >Who loves ya. Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore!
    http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING
    http://pages.ivillage.com/ironjustice/deadpeoplewalking
     
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