D
Doe
Guest
>>snip<<
In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
properties of the bisphosphonates are due to their iron chelating characteristics.
>>snip<<
Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links
Selective in vitro antioxidant properties of bisphosphonates.
Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.
Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium
The aim of this study was to investigate the in vitro antioxidant profile of different
bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
peroxidation inhibiting capacity. Furthermore, the
effect of these different compounds on DPPH, a stable radical, was investigated. Clodronate,
risedronate, and pyrophosphate were further tested for their hydroxyl radical scavenging activity.
None of the tested compounds showed xanthine oxidase inhibiting activity or DPPH scavenging
activity. All the tested bisphosphonates exhibited inhibiting capacities on the microsomal lipid
peroxidation. The hydroxyl radical scavenging activity was dependent on the order of adding the
different reagents and was highest for risedronate. Bisphosphonates possess an inhibiting activity
on the microsomal lipid peroxidation and the Fenton reaction. In these reactions iron plays an
important role suggesting that the selective in vitro antioxidant properties of the bisphosphonates
are due to
their iron chelating characteristics.
PMID: 14741688 [PubMed - in process]
------------------------------------------------------------------------------
--
Br J Radiol. 2002 May; 75(893): 467-9. Related Articles, Links
Complete healing of severe osteoradionecrosis with treatment combining
pentoxifylline, tocopherol and clodronate.
Delanian S, Lefaix JL.
Service d'Oncologie-Radiotherapie, Hopital Saint-Louis APHP, 1 Ave Claude
Vellefaux, 75010 Paris, France.
Osteoradionecrosis (ORN) is a late terminal sequela of irradiation that does
not resolve spontaneously. In a preliminary study, a combination of
pentoxifylline (PTX), tocopherol (Vit-E) and clodonate has been shown to be of
clinical
benefit with more than 50% regression of progressive ORN observed at 6 months
in 12 patients. A 68-year-old woman presenting with severe exteriorized
osteoradionecrosis had received radiotherapy for breast cancer 29 years
previously.
She had palpable breast fibrosis, including the sternum (15 cm x 11 cm) and a
painful fistulous track in the upper part of the bone (orifice diameter 10 mm)
surrounded by local inflammatory signs, and chronic osteitis with sequestra
extrusion. MRI showed deep radiation-induced fibrosis below this area without
cancer recurrence, and complete bone destruction over an area of 7 cm x 4 cm.
Oral PTX (800 mg day(-1)), Vit.E (1000 IU day(-1)) and clodronate (1600 mg
day(-1)) were administered daily for 3 years and were well tolerated. The
patient
exhibited regular clinical improvement until complete closure of the fistula
and total regression of the clinical fibrosis. MRI confirmed the good response
and showed heterogeneous restoration of the sternum, which was filled with new
tissue. This is the first time that antifibrotic treatment with combined
PTX-Vit.E plus clodronate has been shown to have a significant effect on
necrosis,
by completely reversing severe progressive ORN and the associated
radiation-induced fibrosis.
Publication Types:
Case Reports
PMID: 12036843 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------------------
--
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
properties of the bisphosphonates are due to their iron chelating characteristics.
>>snip<<
Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links
Selective in vitro antioxidant properties of bisphosphonates.
Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.
Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium
The aim of this study was to investigate the in vitro antioxidant profile of different
bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
peroxidation inhibiting capacity. Furthermore, the
effect of these different compounds on DPPH, a stable radical, was investigated. Clodronate,
risedronate, and pyrophosphate were further tested for their hydroxyl radical scavenging activity.
None of the tested compounds showed xanthine oxidase inhibiting activity or DPPH scavenging
activity. All the tested bisphosphonates exhibited inhibiting capacities on the microsomal lipid
peroxidation. The hydroxyl radical scavenging activity was dependent on the order of adding the
different reagents and was highest for risedronate. Bisphosphonates possess an inhibiting activity
on the microsomal lipid peroxidation and the Fenton reaction. In these reactions iron plays an
important role suggesting that the selective in vitro antioxidant properties of the bisphosphonates
are due to
their iron chelating characteristics.
PMID: 14741688 [PubMed - in process]
------------------------------------------------------------------------------
--
Br J Radiol. 2002 May; 75(893): 467-9. Related Articles, Links
Complete healing of severe osteoradionecrosis with treatment combining
pentoxifylline, tocopherol and clodronate.
Delanian S, Lefaix JL.
Service d'Oncologie-Radiotherapie, Hopital Saint-Louis APHP, 1 Ave Claude
Vellefaux, 75010 Paris, France.
Osteoradionecrosis (ORN) is a late terminal sequela of irradiation that does
not resolve spontaneously. In a preliminary study, a combination of
pentoxifylline (PTX), tocopherol (Vit-E) and clodonate has been shown to be of
clinical
benefit with more than 50% regression of progressive ORN observed at 6 months
in 12 patients. A 68-year-old woman presenting with severe exteriorized
osteoradionecrosis had received radiotherapy for breast cancer 29 years
previously.
She had palpable breast fibrosis, including the sternum (15 cm x 11 cm) and a
painful fistulous track in the upper part of the bone (orifice diameter 10 mm)
surrounded by local inflammatory signs, and chronic osteitis with sequestra
extrusion. MRI showed deep radiation-induced fibrosis below this area without
cancer recurrence, and complete bone destruction over an area of 7 cm x 4 cm.
Oral PTX (800 mg day(-1)), Vit.E (1000 IU day(-1)) and clodronate (1600 mg
day(-1)) were administered daily for 3 years and were well tolerated. The
patient
exhibited regular clinical improvement until complete closure of the fistula
and total regression of the clinical fibrosis. MRI confirmed the good response
and showed heterogeneous restoration of the sternum, which was filled with new
tissue. This is the first time that antifibrotic treatment with combined
PTX-Vit.E plus clodronate has been shown to have a significant effect on
necrosis,
by completely reversing severe progressive ORN and the associated
radiation-induced fibrosis.
Publication Types:
Case Reports
PMID: 12036843 [PubMed - indexed for MEDLINE]
------------------------------------------------------------------------------
--
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking